The Impact of Mechano-Electric Feedback on Drug- and Stretch- Induced Arrhythmia Using a Computational Model of Cardiac Electromechanics
Asencio A, Buonocunto M, Ellis M, Munthe K, Stark K, Sundnes J, Finsberg H, Arevalo H. The Impact of Mechano-Electric Feedback on Drug- and Stretch- Induced Arrhythmia Using a Computational Model of Cardiac Electromechanics. Simula SpringerBriefs On Computing 2024, 17: 87-97. DOI: 10.1007/978-3-031-53145-3_6.Peer-Reviewed Original ResearchStretch-activated ion channelsMechano-electrical feedbackCardiac cellsO’Hara-RudyIncreased arrhythmic riskAction potential durationAnti-arrhythmic drugsPro-arrhythmic drugsStretch-induced arrhythmiasPro-arrhythmic effectsCoupled electro-mechanical modelElectro-mechanical modelComputational models of cardiac electromechanicsArrhythmic riskPotential durationHeart failureModels of cardiac electromechanicsElectrophysiological parametersInfarction patientsPathological stretchRisk classificationRisk profileCardiac electrophysiologyIon channelsAnti-arrhythmic compounds