2012
Mesenchymal stem cells: therapeutic outlook for stroke
Honmou O, Onodera R, Sasaki M, Waxman SG, Kocsis JD. Mesenchymal stem cells: therapeutic outlook for stroke. Trends In Molecular Medicine 2012, 18: 292-297. PMID: 22459358, DOI: 10.1016/j.molmed.2012.02.003.Peer-Reviewed Original ResearchConceptsMarrow-derived mesenchymal stem cellsTransplanted MSCsSpinal cord injuryInitial clinical studiesInitial human studiesBone marrow-derived mesenchymal stem cellsAdult bone marrow-derived mesenchymal stem cellsAdult human bone marrowAxonal sproutingCerebral ischemiaClinical outcomesNeuroprotective effectsCord injuryHuman bone marrowClinical studiesTherapeutic effectStroke modelAnimal modelsHuman studiesBone marrowMesenchymal stem cellsIntravenous deliveryTherapeutic outlookMSC deliveryStroke
2008
18 MULTIPLE SCLEROSIS: REMYELINATION
KOCSIS J, SASAKI M, LANKFORD K, RADTKE C. 18 MULTIPLE SCLEROSIS: REMYELINATION. 2008, 413-435. DOI: 10.1016/b978-012373994-0.50020-8.Peer-Reviewed Original ResearchMyelin-forming cellsMultiple sclerosisConduction abnormalitiesPotential neuroprotective effectsProminent pathological featurePeripheral nervous systemEndogenous progenitor cellsPotassium channel distributionRemyelinated axonsIon channel organizationDemyelinated lesionsNeuroprotective effectsAxonal transectionPathological featuresFunctional deficitsMyelin repairAxonal repairMyelin resultsNervous systemImpulse conductionProgenitor cellsRemyelinationSclerosisTransectionAbnormalities
2005
Protection of corticospinal tract neurons after dorsal spinal cord transection and engraftment of olfactory ensheathing cells
Sasaki M, Hains BC, Lankford KL, Waxman SG, Kocsis JD. Protection of corticospinal tract neurons after dorsal spinal cord transection and engraftment of olfactory ensheathing cells. Glia 2005, 53: 352-359. PMID: 16288464, PMCID: PMC2605395, DOI: 10.1002/glia.20285.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzimidazolesCell CountCell SeparationCell SurvivalCell TransplantationEnzyme-Linked Immunosorbent AssayFluorescent DyesImage Processing, Computer-AssistedImmunohistochemistryIn Situ Nick-End LabelingMotor ActivityNeuronsOlfactory PathwaysPyramidal TractsRatsSpinal Cord InjuriesStilbamidinesConceptsCorticospinal tract neuronsSpinal cordTract neuronsNeuronal lossOEC transplantationDorsal spinal cord transectionPrimary motor cortexCortical projection neuronsSpinal cord transectionTransplantation of olfactoryRat spinal cordOlfactory Ensheathing CellsApoptotic cortical neuronsBDNF levelsNeuroprotective effectsCord transectionFunctional outcomeMotor cortexNeurotrophic moleculesProjection neuronsAxonal regenerationCortical neuronsInjury zoneTransplantationOECs