2021
Weight gain in menopause: systematic review of adverse events in women treated with black cohosh
Naser B, Castelo-Branco C, Meden H, Minkin M, Rachoń D, Beer A, Pickartz S. Weight gain in menopause: systematic review of adverse events in women treated with black cohosh. Climacteric 2021, 25: 220-227. PMID: 34608830, DOI: 10.1080/13697137.2021.1973993.Peer-Reviewed Original ResearchConceptsAdverse eventsWeight gainSpontaneous adverse eventsBody fat compositionScientific evidencePopular treatment optionPostmenopausal womenMenopausal womenMenopausal symptomsTreatment optionsCase reportTreatment groupsSystematic reviewBlack cohoshFat compositionWeight changeWomenSignificant differencesFrequent problemPerimenopausalMenopauseReviewGroupSymptomsCases
2020
Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence
Castelo-Branco C, Gambacciani M, Cano A, Minkin M, Rachoń D, Ruan X, Beer A, Schnitker J, Henneicke-von Zepelin H, Pickartz S. Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence. Climacteric 2020, 24: 109-119. PMID: 33021111, DOI: 10.1080/13697137.2020.1820477.Peer-Reviewed Original ResearchConceptsClimacteric symptomsMenopausal symptomsBetter benefit-risk profileLow-dose transdermal estradiolICR/Evidence-based treatment optionsEstrogen-sensitive organsEstrogen-sensitive tissuesPsychological menopausal symptomsMinor adverse eventsBenefit-risk profileEvidence of hepatotoxicityGood safety profileStandardized mean differenceHormone-dependent diseasesSystematic literature searchTransdermal estradiolAdverse eventsGood tolerabilitySafety profileTreatment optionsSt. John's wortHerbal therapyHormone levelsClinical dataEffects of combined 17β-estradiol and progesterone on weight and blood pressure in postmenopausal women of the REPLENISH trial
Black D, Minkin M, Graham S, Bernick B, Mirkin S. Effects of combined 17β-estradiol and progesterone on weight and blood pressure in postmenopausal women of the REPLENISH trial. Menopause The Journal Of The North American Menopause Society 2020, 28: 32-39. PMID: 32932401, PMCID: PMC7769186, DOI: 10.1097/gme.0000000000001659.Peer-Reviewed Original ResearchConceptsE2/P4Diastolic blood pressureSystolic blood pressureBlood pressurePostmenopausal womenREPLENISH trialMonth 12Treatment-emergent adverse eventsWeight gainTwelve-month useHealthy postmenopausal womenSevere vasomotor symptomsBody mass indexAdverse eventsVasomotor symptomsMass indexEfficacy profileWomenBaselineHypertensionPlaceboUterusTrialsImportant changesPrevious findings