Inflamed but not impulsive: Acute inflammatory cytokine response does not impact prepotent response inhibition
Madison A, Andridge R, Renna M, Sheridan J, Lustberg M, Ramaswamy B, Wesolowski R, Williams N, Sardesai S, Noonan A, Reinbolt R, Cherian M, Malarkey W, Kiecolt-Glaser J. Inflamed but not impulsive: Acute inflammatory cytokine response does not impact prepotent response inhibition. Journal Of Affective Disorders 2023, 342: 1-9. PMID: 37683942, PMCID: PMC10591975, DOI: 10.1016/j.jad.2023.09.008.Peer-Reviewed Original ResearchConceptsInflammatory cytokine responseCytokine responsesCancer survivorsTyphoid vaccineConners' Continuous Performance TestPostmenopausal breast cancer survivorsInterleukin-1 receptor antagonistResponse inhibitionBreast cancer survivorsInterleukin-6 responseSaline placebo injectionsOutcomes of interestPolysaccharide vaccinationPlacebo injectionsCrossover trialReceptor antagonistSeparate visitsContinuous Performance TestSecondary analysisAspects of impulsivityPlaceboNon-significant resultsPrepotent response inhibitionVaccineInjectionConflicts hurt: social stress predicts elevated pain and sadness after mild inflammatory increases
Madison A, Renna M, Andridge R, Peng J, Shrout M, Sheridan J, Lustberg M, Ramaswamy B, Wesolowski R, Williams N, Noonan A, Reinbolt R, Stover D, Cherian M, Malarkey W, Kiecolt-Glaser J. Conflicts hurt: social stress predicts elevated pain and sadness after mild inflammatory increases. Pain 2023, 164: 1985-1994. PMID: 36943254, PMCID: PMC10440304, DOI: 10.1097/j.pain.0000000000002894.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsCancer survivorsChronic social stressPostmenopausal breast cancer survivorsInterleukin-1 receptor antagonistSocial stressEffects of inflammationAcute inflammatory responseSaline placeboChronic painElevated painMore painReceptor antagonistInterleukin-6Inflammatory responseHours postinjectionDepression riskPainInflammatory increasesNervous systemSeparate visitsNonsocial stressVaccine sequenceBehavioral covariatesInflammation