2024
Effect of minocycline on changes in affective behaviors, cognitive function, and inflammation in breast cancer survivors undergoing chemotherapy: a pilot randomized controlled trial
Melink Z, Lustberg M, Schnell P, Mezzanotte-Sharpe J, Orchard T. Effect of minocycline on changes in affective behaviors, cognitive function, and inflammation in breast cancer survivors undergoing chemotherapy: a pilot randomized controlled trial. Breast Cancer Research And Treatment 2024, 208: 605-617. PMID: 39143391, PMCID: PMC11522141, DOI: 10.1007/s10549-024-07457-w.Peer-Reviewed Original ResearchState-Trait Anxiety InventoryCES-DRandomized controlled trialsBC survivorsCancer survivorsEpidemiologic Studies Depression ScaleEffects of minocyclineBreast cancer survivorsCES-D scoresCognitive functionStage I-III BCSelf-reported cognitionCohort of BC survivorsBreast cancerAffective behaviorBaseline to 6Depression ScaleSub-group analysisInflammatory markersPost-chemotherapyAnxiety InventoryInterleukin-8State-TraitBaseline scoresControlled trials
2023
Depression, Inflammation, and Intestinal Permeability: Associations with Subjective and Objective Cognitive Functioning throughout Breast Cancer Survivorship
Madison A, Andridge R, Kantaras A, Renna M, Bennett J, Alfano C, Povoski S, Agnese D, Lustberg M, Wesolowski R, Carson W, Williams N, Reinbolt R, Sardesai S, Noonan A, Stover D, Cherian M, Malarkey W, Kiecolt-Glaser J. Depression, Inflammation, and Intestinal Permeability: Associations with Subjective and Objective Cognitive Functioning throughout Breast Cancer Survivorship. Cancers 2023, 15: 4414. PMID: 37686689, PMCID: PMC10487080, DOI: 10.3390/cancers15174414.Peer-Reviewed Original ResearchBreast cancer survivorsSignificant depressive symptomsIntestinal permeabilityCancer survivorsDepressive symptomsObjective cognitive functionCognitive functionStudy visitCognitive declineEpidemiological Studies Depression ScaleCancer treatment typeInflammation-associated depressionC-reactive proteinCancer Survivor StudyBreast cancer survivorshipTumor necrosis factorCognitive function testsLipopolysaccharide binding proteinHopkins Verbal Learning TestSubjective cognitive functionObjective cognitive impairmentLower verbal fluencyInflammatory indexInflammatory markersElevated inflammation
2022
The Association of Serum Inflammatory Markers and Self-Reported Cognitive Outcomes in Women With Breast Cancer Undergoing Chemotherapy
Zhang Z, Schnell P, Ormiston K, Weinhold K, Kopec R, Lustberg M, Orchard T. The Association of Serum Inflammatory Markers and Self-Reported Cognitive Outcomes in Women With Breast Cancer Undergoing Chemotherapy. Current Developments In Nutrition 2022, 6: 6009258. PMCID: PMC9193788, DOI: 10.1093/cdn/nzac052.025.Peer-Reviewed Original ResearchSerum inflammatory markersInflammatory markersSelf-reported cognitive functionBreast cancerIL-1βTNF-RIICognitive functionIL-8Lower serum IL-1βHigher tumor necrosis factorHigher interleukin-8Lower interleukin-1βSerum omega-3Serum IL-1βLower IL-1βTumor necrosis factorEnzyme-linked immunoassayAdjuvant chemotherapyInterleukin-1βInterleukin-6Cognitive dysfunctionInterleukin-8Necrosis factorQuestionnaire scoresChemotherapy
2021
Changes in Inflammatory Markers and Correlations with Serum Polyunsaturated Fatty Acids In Postmenopausal Women With Breast Cancer Undergoing Chemotherapy
Zhang Z, Ormiston K, Weinhold K, Schnell P, Kopec R, Lustberg M, Orchard T. Changes in Inflammatory Markers and Correlations with Serum Polyunsaturated Fatty Acids In Postmenopausal Women With Breast Cancer Undergoing Chemotherapy. Journal Of The Academy Of Nutrition And Dietetics 2021, 121: a18. DOI: 10.1016/j.jand.2021.06.034.Peer-Reviewed Original ResearchChanges in Serum Fatty Acids and Inflammatory Markers in Postmenopausal Women With Breast Cancer Following Chemotherapy Treatment
Zhang Z, Ormiston K, Schnell P, Kopec R, Lustberg M, Orchard T. Changes in Serum Fatty Acids and Inflammatory Markers in Postmenopausal Women With Breast Cancer Following Chemotherapy Treatment. Current Developments In Nutrition 2021, 5: 5140290. PMCID: PMC8182042, DOI: 10.1093/cdn/nzab036_032.Peer-Reviewed Original ResearchSerum fatty acidsInflammatory markersInterleukin-6Breast cancerSerum cytokinesPostmenopausal breast cancer patientsSerum inflammatory markersBreast cancer survivorsBreast cancer patientsFatty acidsMethods Serum samplesTumor necrosis factorTotal monounsaturated FAsTotal monounsaturated fatty acidsEnzyme-linked immunoassaySerum FCytokine changesPostmenopausal womenInflammatory profileCancer survivorsInflammatory stateCancer patientsIL-8Chemotherapy treatmentNecrosis factorPhase II double blinded randomized placebo-controlled trial of minocycline to ameliorate chemotherapy-induced cognitive changes in breast cancer (BC) patients.
Sharpe J, Schnell P, Knopp M, Binzel K, Magyer M, Cherian M, Gatti-Mays M, Pariser A, Wesolowski R, Sardesai S, VanDeusen J, Stover D, Ramaswamy B, Williams N, DeVries A, Shinde N, Orchard T, Lustberg M. Phase II double blinded randomized placebo-controlled trial of minocycline to ameliorate chemotherapy-induced cognitive changes in breast cancer (BC) patients. Journal Of Clinical Oncology 2021, 39: e12528-e12528. DOI: 10.1200/jco.2021.39.15_suppl.e12528.Peer-Reviewed Original ResearchPET/CT imagingPET/CTCytokine levelsMicroglial activationCT imagingF-fluorodeoxyglucoseDouble-blinded randomized placebo-controlled trialBlinded randomized placebo-controlled trialChemotherapy-induced cognitive changesRandomized placebo-controlled trialCognitive functionPlacebo-controlled trialInflammatory cytokine levelsBreast cancer patientsCognitive changesCT brain imagingAC therapyDaily minocyclinePotent mitigatorNeoadjuvant chemotherapyPlacebo groupInflammatory markersInflammatory changesMedian ageMinocycline group
2015
Healthy Eating Index Scores are Associated with Inflammatory Markers in Breast Cancer Survivors
Arnold K, Andridge R, Logan A, Yee L, Lustberg M, Orchard T. Healthy Eating Index Scores are Associated with Inflammatory Markers in Breast Cancer Survivors. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.lb267.Peer-Reviewed Original ResearchHealthy Eating Index 2010Breast cancer survivorsTumor necrosis factor alpha receptor 2Cancer survivorsHEI scoresDiet qualityInflammatory markersIL-17IL-6Breast cancerTNFR-2Randomized placebo-controlled pilot studyOmega-3 Fatty Acid SupplementationPlacebo-controlled pilot studyEarly-stage breast cancerHealthy Eating Index scoreHealthier diet qualityStage breast cancerLower IL-6Fatty acid supplementationAromatase inhibitor treatmentAI therapyChemotherapy statusPrior chemotherapyPostmenopausal women