2024
Impact of HER2 low status on genomic signatures in triple negative breast cancer (TNBC).
Taylor M, Reddy S, Ashok Kumar P, Hariri D, Sokol E, Sivakumar S, Quintanilha J, Pavlick D, Levy M, Ross J, Lustberg M. Impact of HER2 low status on genomic signatures in triple negative breast cancer (TNBC). Journal Of Clinical Oncology 2024, 42: 1092-1092. DOI: 10.1200/jco.2024.42.16_suppl.1092.Peer-Reviewed Original ResearchTriple negative breast cancerComprehensive genomic profilingGenomic alterationsHER2 statusHER2 2Triple negative breast cancer groupGA frequencyReview of pathology specimensHER2 IHC expressionHER2-low statusHER2-low tumorsLack of clinical dataPD-L1 expressionTumor mutational burdenHER2 IHC scoreHER2 2+Negative breast cancerEvaluate genomic alterationsMann-Whitney U testPotential treatment optionStatistically significant differenceHER2 subgroupsPD-L1Immunotherapy biomarkersChi-square test
2023
Prevalence of targetable genomic alterations in young women with advanced breast cancer: a cross-sectional study
Blansky D, Ansari N, Gao L, Sokol E, Sivakumar S, Huang R, Pelletier M, Levy M, Pavlick D, Danziger N, Ross J, Lustberg M, Rozenblit M. Prevalence of targetable genomic alterations in young women with advanced breast cancer: a cross-sectional study. Breast Cancer Research And Treatment 2023, 204: 181-185. PMID: 37999916, DOI: 10.1007/s10549-023-07179-5.Peer-Reviewed Original ResearchComprehensive genomic profilingBreast cancerYoung womenGenomic alterationsAdvanced breast cancerPD-L1 expressionTargetable genomic alterationsWorse clinical outcomesTime of diagnosisTumor mutational burdenCross-sectional studyBreast cancer casesFoundation MedicineClinical outcomesPIK3CA mutationsCancer casesEstrogen receptorMutational burdenOlder womenConclusionOur findingsTotal casesBreast tumorsTumor tissueBRCA1 mutationsMicrosatellite instability
2022
Targetable genomic mutations in young women with advanced breast cancer.
Ansari N, Gao L, Sokol E, Sivakumar S, Huang R, Pelletier M, Levy M, Pavlick D, Danziger N, Ross J, Lustberg M, Rozenblit M. Targetable genomic mutations in young women with advanced breast cancer. Journal Of Clinical Oncology 2022, 40: 1027-1027. DOI: 10.1200/jco.2022.40.16_suppl.1027.Peer-Reviewed Original ResearchComprehensive genomic profilingTumor mutational burdenAdvanced breast cancerPD-L1 expressionBreast cancerYoung womenImmune therapyPIK3CA mutationsGenomic alterationsTumor cell PD-L1 expressionClasses of GAsRB1 mutationsDisease-free survivalActionable genomic alterationsDifferent mutational profilesPARP inhibitor useImmunotherapy optionsInhibitor useFoundation MedicineLymph nodesWorse prognosisBRCA2 mutationsEstrogen receptorMutational burdenOlder womenThe mutational profile of ER-, PR+, HER2- metastatic breast cancer.
Fischbach N, Huang R, Lustberg M, Pelletier M, Pusztai L, Sivakumar S, Sokol E, Ross J, Levy M. The mutational profile of ER-, PR+, HER2- metastatic breast cancer. Journal Of Clinical Oncology 2022, 40: 1025-1025. DOI: 10.1200/jco.2022.40.16_suppl.1025.Peer-Reviewed Original ResearchTriple-negative breast cancerComprehensive genomic profilingMetastatic breast cancerBreast cancerClinical trialsPathology reportsMutational profileHER2- metastatic breast cancerConsecutive breast cancersAnti-estrogen therapyNegative breast cancerPD-L1 IHCPotential therapeutic implicationsHigh rateEndocrine therapyEstrogen therapyPatient ageFoundation MedicineKRAS alterationsRare subtypeHER2 expressionClinical behaviorReceptor phenotypeBreast carcinomaTreatment strategies
2016
Decision impact analysis of comprehensive genomic profiling (CGP) in advanced breast cancer: A prospective study.
Reinbolt R, Tolliver K, Abdel-Rasoul M, Timmers C, Ramaswamy B, Layman R, Wesolowski R, Mrozek E, Gillespie S, Chen J, Ali S, Balasubramanian S, Shapiro C, Ostrowski M, Leone G, Macrae E, Lustberg M. Decision impact analysis of comprehensive genomic profiling (CGP) in advanced breast cancer: A prospective study. Journal Of Clinical Oncology 2016, 34: 11578-11578. DOI: 10.1200/jco.2016.34.15_suppl.11578.Peer-Reviewed Original ResearchComprehensive genomic profilingAdvanced breast cancerProspective studyBreast cancerGenomic profilingDecision impact analysis