2024
Effect of minocycline on changes in affective behaviors, cognitive function, and inflammation in breast cancer survivors undergoing chemotherapy: a pilot randomized controlled trial
Melink Z, Lustberg M, Schnell P, Mezzanotte-Sharpe J, Orchard T. Effect of minocycline on changes in affective behaviors, cognitive function, and inflammation in breast cancer survivors undergoing chemotherapy: a pilot randomized controlled trial. Breast Cancer Research And Treatment 2024, 208: 605-617. PMID: 39143391, PMCID: PMC11522141, DOI: 10.1007/s10549-024-07457-w.Peer-Reviewed Original ResearchState-Trait Anxiety InventoryCES-DRandomized controlled trialsBC survivorsCancer survivorsEpidemiologic Studies Depression ScaleEffects of minocyclineBreast cancer survivorsCES-D scoresCognitive functionStage I-III BCSelf-reported cognitionCohort of BC survivorsBreast cancerAffective behaviorBaseline to 6Depression ScaleSub-group analysisInflammatory markersPost-chemotherapyAnxiety InventoryInterleukin-8State-TraitBaseline scoresControlled trialsAdherence to a MIND Diet Pattern Is Associated With Better Cognitive Function and Less Peripheral Inflammation in Breast Cancer Survivors
Orchard T, Winschel T, Weinhold K, Melink Z, Aase D, Schnell P, Gorka S, Lustberg M, Williams N. Adherence to a MIND Diet Pattern Is Associated With Better Cognitive Function and Less Peripheral Inflammation in Breast Cancer Survivors. Current Developments In Nutrition 2024, 8: 103175. DOI: 10.1016/j.cdnut.2024.103175.Peer-Reviewed Original Research
2023
Depression, Inflammation, and Intestinal Permeability: Associations with Subjective and Objective Cognitive Functioning throughout Breast Cancer Survivorship
Madison A, Andridge R, Kantaras A, Renna M, Bennett J, Alfano C, Povoski S, Agnese D, Lustberg M, Wesolowski R, Carson W, Williams N, Reinbolt R, Sardesai S, Noonan A, Stover D, Cherian M, Malarkey W, Kiecolt-Glaser J. Depression, Inflammation, and Intestinal Permeability: Associations with Subjective and Objective Cognitive Functioning throughout Breast Cancer Survivorship. Cancers 2023, 15: 4414. PMID: 37686689, PMCID: PMC10487080, DOI: 10.3390/cancers15174414.Peer-Reviewed Original ResearchBreast cancer survivorsSignificant depressive symptomsIntestinal permeabilityCancer survivorsDepressive symptomsObjective cognitive functionCognitive functionStudy visitCognitive declineEpidemiological Studies Depression ScaleCancer treatment typeInflammation-associated depressionC-reactive proteinCancer Survivor StudyBreast cancer survivorshipTumor necrosis factorCognitive function testsLipopolysaccharide binding proteinHopkins Verbal Learning TestSubjective cognitive functionObjective cognitive impairmentLower verbal fluencyInflammatory indexInflammatory markersElevated inflammationVegetable Intake Is Associated with Better Cognitive Function in Post-menopausal Breast Cancer Survivors
Weinhold K, Melink Z, Aase D, Belury M, Cole R, Lustberg M, Gorka S, Schnell P, Williams N, Stevens E, Oppong B, Orchard T. Vegetable Intake Is Associated with Better Cognitive Function in Post-menopausal Breast Cancer Survivors. Journal Of The Academy Of Nutrition And Dietetics 2023, 123: a78. DOI: 10.1016/j.jand.2023.06.274.Peer-Reviewed Original Research
2022
Social Support, social ties, and cognitive function of women with breast cancer: findings from the Women’s Health Initiative (WHI) Life and Longevity After Cancer (LILAC) Study
Yang Y, McLaughlin E, Naughton M, Lustberg M, Nolan T, Kroenke C, Weitlauf J, Saquib N, Shadyab A, Follis S, Pan K, Paskett E. Social Support, social ties, and cognitive function of women with breast cancer: findings from the Women’s Health Initiative (WHI) Life and Longevity After Cancer (LILAC) Study. Supportive Care In Cancer 2022, 31: 48. PMID: 36525119, PMCID: PMC9758078, DOI: 10.1007/s00520-022-07505-5.Peer-Reviewed Original ResearchConceptsWomen's Health Initiative (WHI) LifeBreast cancerMedian cognitive scoresCognitive functionCognitive scoresBreast cancer stage IMedical Outcomes Study Social Support SurveySocial supportCognitive functioningCancer stage IHigher social support scoresSocial Support SurveyMultivariable quantile regressionHigher cognitive functioningNon-Hispanic whitesSelf-reported cognitive functioningSocial support scoresMajority of participantsBaseline questionnaireCancer cohortHigh riskMethodsThe studyKruskal-Wallis testStage IHigh social supportThe Association of Serum Inflammatory Markers and Self-Reported Cognitive Outcomes in Women With Breast Cancer Undergoing Chemotherapy
Zhang Z, Schnell P, Ormiston K, Weinhold K, Kopec R, Lustberg M, Orchard T. The Association of Serum Inflammatory Markers and Self-Reported Cognitive Outcomes in Women With Breast Cancer Undergoing Chemotherapy. Current Developments In Nutrition 2022, 6: 6009258. PMCID: PMC9193788, DOI: 10.1093/cdn/nzac052.025.Peer-Reviewed Original ResearchSerum inflammatory markersInflammatory markersSelf-reported cognitive functionBreast cancerIL-1βTNF-RIICognitive functionIL-8Lower serum IL-1βHigher tumor necrosis factorHigher interleukin-8Lower interleukin-1βSerum omega-3Serum IL-1βLower IL-1βTumor necrosis factorEnzyme-linked immunoassayAdjuvant chemotherapyInterleukin-1βInterleukin-6Cognitive dysfunctionInterleukin-8Necrosis factorQuestionnaire scoresChemotherapy
2021
Phase II double blinded randomized placebo-controlled trial of minocycline to ameliorate chemotherapy-induced cognitive changes in breast cancer (BC) patients.
Sharpe J, Schnell P, Knopp M, Binzel K, Magyer M, Cherian M, Gatti-Mays M, Pariser A, Wesolowski R, Sardesai S, VanDeusen J, Stover D, Ramaswamy B, Williams N, DeVries A, Shinde N, Orchard T, Lustberg M. Phase II double blinded randomized placebo-controlled trial of minocycline to ameliorate chemotherapy-induced cognitive changes in breast cancer (BC) patients. Journal Of Clinical Oncology 2021, 39: e12528-e12528. DOI: 10.1200/jco.2021.39.15_suppl.e12528.Peer-Reviewed Original ResearchPET/CT imagingPET/CTCytokine levelsMicroglial activationCT imagingF-fluorodeoxyglucoseDouble-blinded randomized placebo-controlled trialBlinded randomized placebo-controlled trialChemotherapy-induced cognitive changesRandomized placebo-controlled trialCognitive functionPlacebo-controlled trialInflammatory cytokine levelsBreast cancer patientsCognitive changesCT brain imagingAC therapyDaily minocyclinePotent mitigatorNeoadjuvant chemotherapyPlacebo groupInflammatory markersInflammatory changesMedian ageMinocycline group
2020
The Effects of Omega-3 Supplementation and Doxorubicin-Based Chemotherapy on the Murine Brain Lipidome
Bennouna D, Solano M, Orchard T, DeVries A, Lustberg M, Kopec R. The Effects of Omega-3 Supplementation and Doxorubicin-Based Chemotherapy on the Murine Brain Lipidome. Current Developments In Nutrition 2020, 4: nzaa044_008. PMCID: PMC7257705, DOI: 10.1093/cdn/nzaa044_008.Peer-Reviewed Original ResearchLast injectionOmega-3 supplementationOvariectomized C57BL/6 miceChemotherapy injectionsSupplemental EPADHA supplementationResolvin E1Resolvin D1Resolvin D2C57BL/6 miceDietary groupsResolvin D5Whole brainResolvin D3Cognitive functionSupplementationLipidomic analysisSignificant differencesInjectionSubset of samplesDaysStudy 2RvD3Study 1Cyclophosphamide