2024
Low sucrose diets protect long-term memory and EPA & DHA enriched diets alter insulin resistance in a mouse model of chemotherapy
Ormiston K, Fitzgerald J, Andridge R, Lustberg M, DeVries A, Orchard T. Low sucrose diets protect long-term memory and EPA & DHA enriched diets alter insulin resistance in a mouse model of chemotherapy. Nutrition Research 2024, 131: 39-53. PMID: 39368285, DOI: 10.1016/j.nutres.2024.09.004.Peer-Reviewed Original ResearchLiver lipid contentMouse model of chemotherapyLipid contentBody weightLong-term memorySucrose dietLow-sucrose dietDocosahexaenoic acidInsulin resistanceChemotherapy-related cognitive impairmentMouse modelEffects of EPA+DHADoxorubicin-based chemotherapyFemale C57BL/6 miceImpact of chemotherapyAltered insulin resistanceNegatively impacts quality of lifeInsulin resistance scoreDietResistance scoreLower sucrose consumptionEPA+DHARandomized to 1Affective side effectsEicosapentaenoic acid + docosahexaenoic acidFeasibility and metabolic outcomes of a well-formulated ketogenic diet as an adjuvant therapeutic intervention for women with stage IV metastatic breast cancer: The Keto-CARE trial
Buga A, Harper D, Sapper T, Hyde P, Fell B, Dickerson R, Stoner J, Kackley M, Crabtree C, Decker D, Robinson B, Krystal G, Binzel K, Lustberg M, Volek J. Feasibility and metabolic outcomes of a well-formulated ketogenic diet as an adjuvant therapeutic intervention for women with stage IV metastatic breast cancer: The Keto-CARE trial. PLOS ONE 2024, 19: e0296523. PMID: 38166036, PMCID: PMC10760925, DOI: 10.1371/journal.pone.0296523.Peer-Reviewed Original ResearchConceptsMetastatic breast cancerStage IV metastatic breast cancerKetogenic dietInsulin resistanceNutritional ketosisPlasma insulinBreast cancerBody compositionAdjuvant therapeutic interventionsMetabolic outcomesCancer patientsPlasma glucoseMetabolic effectsBody fatShort-term studiesBody weightPleiotropic mechanismsTherapeutic interventionsConsistent bloodPhase IMonthsWomenCancerAd libitumChemotherapy
2022
Episodic future thinking: A behavioral intervention to promote weight loss in breast cancer survivors.
Sukumar J, Vaughn J, Stein J, Schnell P, Sudheendra P, Pariser A, Gatti-Mays M, Williams N, Cherian M, Stover D, Wesolowski R, Ramaswamy B, Lustberg M, Sardesai S. Episodic future thinking: A behavioral intervention to promote weight loss in breast cancer survivors. Journal Of Clinical Oncology 2022, 40: tps12139-tps12139. DOI: 10.1200/jco.2022.40.16_suppl.tps12139.Peer-Reviewed Original ResearchPrimary endpointSecondary endpointsCancer survivorsBehavioral interventionsBody weightBreast cancer-specific mortalityDiet qualityWeight lossObese BC survivorsCancer-specific mortalityPhase II trialBreast cancer survivorsImproved diet qualityDD ratesEligible patientsHs-CRPII trialObese patientsBC survivorsAdherence ratesInsulin resistanceSpecific mortalitySurvivorship programsEpisodic future thinkingPatient engagement
2020
Effects of Omega-3 Fatty Acids on Insulin Resistance in an Ovariectomized Mouse Model of Diet-Induced Obesity Treated with Chemotherapy
Ormiston K, Zhang Z, Murphy K, DeVries A, Lustberg M, Andridge R, Orchard T. Effects of Omega-3 Fatty Acids on Insulin Resistance in an Ovariectomized Mouse Model of Diet-Induced Obesity Treated with Chemotherapy. Current Developments In Nutrition 2020, 4: nzaa044_044. PMCID: PMC7257328, DOI: 10.1093/cdn/nzaa044_044.Peer-Reviewed Original ResearchInsulin resistanceLF groupBody weightBlood glucoseHF dietHF groupBody fatHigh-fat diet-induced insulin resistanceOmega-3 fatty acidsDiet-induced insulin resistanceLF diet groupHomeostatic model assessmentHOMA-IR scoreDiet-Induced ObesityOvariectomized mouse modelDiet-fed miceLow-fat dietHigh-fat dietLower body weightPercent body fatFasted blood glucoseLower scoresChemotherapy injectionsConclusion ChemotherapySerum insulin