2023
MicroRNA-mediated translational pathways are regulated in the orbitofrontal cortex and peripheral blood samples during acute abstinence from heroin self-administration
Zanda M, Saikali L, Morris P, Daws S. MicroRNA-mediated translational pathways are regulated in the orbitofrontal cortex and peripheral blood samples during acute abstinence from heroin self-administration. Advances In Drug And Alcohol Research 2023, 3: 11668. PMID: 38389822, PMCID: PMC10880771, DOI: 10.3389/adar.2023.11668.Peer-Reviewed Original ResearchHeroin self-administrationOrbitofrontal cortexSelf-administrationDays of forced abstinenceRegulating drug-seeking behaviorSucrose self-administrationDrug-seeking behaviorChronic drug exposureAdult male ratsPeripheral blood samplesHeroin infusionsHeroin seekingMolecular neuroadaptationsForced abstinenceAcute abstinenceNeurobiological consequencesOpioid heroinOpioid misuseHeroinMale ratsSelf-administeredSeeking behaviorAbstinenceBlood samplesOpioid exposure
2022
Heroin Regulates Orbitofrontal Circular RNAs
Floris G, Gillespie A, Zanda M, Dabrowski K, Sillivan S. Heroin Regulates Orbitofrontal Circular RNAs. International Journal Of Molecular Sciences 2022, 23: 1453. PMID: 35163373, PMCID: PMC8836038, DOI: 10.3390/ijms23031453.Peer-Reviewed Original ResearchConceptsHeroin self-administrationOrbitofrontal cortexOpioid use disorderNeurobiological adaptationsSelf-administrationSelf-administer sucroseChronic heroin exposureRat orbitofrontal cortexOpioid-seeking behaviorTreat opioid use disorderHeroin exposureUse disorderBrain regionsOpioid heroinBehavioral responsesMale ratsFemale ratsHeroinSeeking behaviorDrug overdose deathsRatsOverdose deathsOpioidRNA splice variantsCortex