The novel psychoactive substance methoxetamine induces persistent behavioral abnormalities and neurotoxicity in rats
Costa G, Serra M, Pintori N, Casu M, Zanda M, Murtas D, De Luca M, Simola N, Fattore L. The novel psychoactive substance methoxetamine induces persistent behavioral abnormalities and neurotoxicity in rats. Neuropharmacology 2018, 144: 219-232. PMID: 30366005, DOI: 10.1016/j.neuropharm.2018.10.031.Peer-Reviewed Original ResearchConceptsEffects of methoxetamineElevated plus mazePersistent behavioral abnormalitiesBehavioral effectsPlus mazeLocomotor activityBehavioral abnormalitiesDensity of dopamine transportersLocomotor activity of ratsImpaired non-spatial memoryNovel object recognition testEmission of ultrasonic vocalizationsMedial prefrontal cortexMarble burying testVentral tegmental areaPersistent behavioral effectsNon-spatial memoryNovel object recognitionObject recognition testActivity of ratsNeurotoxic effectsSubstantia nigra pars compactaSerotonergic damageNucleus accumbensBurying test