Human neuroblastoma cell lines that express N‐myc without gene amplification
Wada R, Seeger R, Brodeur G, Einhorn P, Rayner S, Tomayko M, Reynolds C. Human neuroblastoma cell lines that express N‐myc without gene amplification. Cancer 1993, 72: 3346-3354. PMID: 8242562, DOI: 10.1002/1097-0142(19931201)72:11<3346::aid-cncr2820721134>3.0.co;2-e.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, NeoplasmAntigens, SurfaceBiomarkers, TumorCatecholaminesCell DivisionChild, PreschoolGene AmplificationGene Expression Regulation, NeoplasticGenes, mycHumansKaryotypingMaleNeuritesNeuroblastomaProto-Oncogene Proteins c-mycTime FactorsTranscriptional ActivationTumor Cells, CulturedConceptsGenomic amplificationN-myc expressionCell linesN-mycNeuroblastoma cell linesUnique genetic rearrangementDouble minute chromosomesGene activationChromosome 2New cell lineGenetic rearrangementsChromosomal deletionsHuman neuroblastoma cell lineBone marrow metastasesStage IV neuroblastomaCell surface antigen expressionN-myc amplificationAggressive tumor behaviorGene amplificationSurface antigen expressionCytogenetic analysisN-myc RNAProgressive diseaseBiological basisMarrow metastases