Featured Publications
Antihypertensive Medications and Serious Fall Injuries in a Nationally Representative Sample of Older Adults
Tinetti ME, Han L, Lee DS, McAvay GJ, Peduzzi P, Gross CP, Zhou B, Lin H. Antihypertensive Medications and Serious Fall Injuries in a Nationally Representative Sample of Older Adults. JAMA Internal Medicine 2014, 174: 588-595. PMID: 24567036, PMCID: PMC4136657, DOI: 10.1001/jamainternmed.2013.14764.Peer-Reviewed Original ResearchConceptsSerious fall injuriesAdjusted hazard ratioAntihypertensive medicationsMultiple chronic conditionsFall injuriesAntihypertensive groupHazard ratioOlder adultsChronic conditionsAntihypertensive medication classesStandardized daily doseAntihypertensive medication useCommunity-living adultsPropensity score adjustmentTraumatic brain injuryHealthy older adultsMedication intensityCardiovascular eventsMedication classesDaily doseHip fractureMedication useNationally Representative SampleHead injuryBrain injuryAnti-Hypertensive Medications and Cardiovascular Events in Older Adults with Multiple Chronic Conditions
Tinetti ME, Han L, McAvay GJ, Lee DS, Peduzzi P, Dodson JA, Gross CP, Zhou B, Lin H. Anti-Hypertensive Medications and Cardiovascular Events in Older Adults with Multiple Chronic Conditions. PLOS ONE 2014, 9: e90733. PMID: 24614535, PMCID: PMC3948696, DOI: 10.1371/journal.pone.0090733.Peer-Reviewed Original ResearchConceptsMultiple chronic conditionsAnti-hypertensive treatmentCardiovascular eventsAnti-hypertensive medicationsHigh-intensity groupChronic conditionsOlder adultsHazard ratioPropensity scoreIntensity groupStandardized daily doseCommunity-living participantsPropensity score adjustmentCV eventsMedication intensityLess comorbidityDaily doseRandomized trialsMAIN OUTCOMERepresentative cohortScore adjustmentSurvey cohortRCT resultsCohortMortalityPotential Therapeutic Competition in Community-Living Older Adults in the U.S.: Use of Medications That May Adversely Affect a Coexisting Condition
Lorgunpai SJ, Grammas M, Lee DS, McAvay G, Charpentier P, Tinetti ME. Potential Therapeutic Competition in Community-Living Older Adults in the U.S.: Use of Medications That May Adversely Affect a Coexisting Condition. PLOS ONE 2014, 9: e89447. PMID: 24586786, PMCID: PMC3934884, DOI: 10.1371/journal.pone.0089447.Peer-Reviewed Original ResearchConceptsChronic conditionsMedication classesDisease guidelinesOlder adultsCommunity-living older adultsCross-sectional descriptive studyAdverse medication effectsCommon chronic conditionsMultiple chronic conditionsUse of medicationsClinical outcomesCoexisting conditionsMedication effectsClinical priorityMedicare claimsMedicationsStudy conditionsAdults 65Systematic reviewDescriptive studyPerson interviewsOlder AmericansAdultsFrequency of usePrevalenceEvaluation of Restorative Care vs Usual Care for Older Adults Receiving an Acute Episode of Home Care
Tinetti ME, Baker D, Gallo WT, Nanda A, Charpentier P, O'Leary J. Evaluation of Restorative Care vs Usual Care for Older Adults Receiving an Acute Episode of Home Care. JAMA 2002, 287: 2098-2105. PMID: 11966384, DOI: 10.1001/jama.287.16.2098.Peer-Reviewed Original ResearchConceptsHome care episodeUsual care patientsCare patientsCare episodesRestorative careCare officesUsual careHome careFunctional statusFunctional declineUsual home careHealth care utilizationSelf-care functionSevere cognitive impairmentReceipt of MedicareHome care servicesAcute episodeBaseline characteristicsOlder patientsCare unitCare utilizationEmergency departmentTotal careHome care agenciesPatients
2023
Changes in Older Adult Trauma Quality When Evaluated Using Longer-Term Outcomes vs In-Hospital Mortality
Zogg C, Cooper Z, Peduzzi P, Falvey J, Castillo-Angeles M, Kodadek L, Staudenmayer K, Davis K, Tinetti M, Lichtman J. Changes in Older Adult Trauma Quality When Evaluated Using Longer-Term Outcomes vs In-Hospital Mortality. JAMA Surgery 2023, 158: e234856. PMID: 37792354, PMCID: PMC10551815, DOI: 10.1001/jamasurg.2023.4856.Peer-Reviewed Original ResearchConceptsHospital-level factorsTraumatic brain injurySevere traumatic brain injuryHospital mortalityTrauma QualityOlder adultsHip fractureComposite scoreHigher risk-adjusted oddsLevel 1 trauma centerIn-Hospital MortalityRisk-adjusted oddsLong-term outcomesMultivariable logistic regressionNontrauma centersTrauma patientsTerm outcomesTrauma centerPrimary diagnosisBrain injuryTrauma systemMAIN OUTCOMEMedicare feeService claimsForms of trauma
2022
Benefits and harms of oral anticoagulants for atrial fibrillation in nursing home residents with advanced dementia
Ouellet GM, O'Leary JR, Leggett CG, Skinner J, Tinetti ME, Cohen AB. Benefits and harms of oral anticoagulants for atrial fibrillation in nursing home residents with advanced dementia. Journal Of The American Geriatrics Society 2022, 71: 561-568. PMID: 36310367, PMCID: PMC9957933, DOI: 10.1111/jgs.18108.Peer-Reviewed Original ResearchConceptsNursing home residentsAtrial fibrillationAdvanced dementiaHome residentsStroke riskLong-stay nursing home residentsMedicare Part D claimsDementia-related mortalityGuideline-recommended thresholdHarms of anticoagulationRetrospective cohort studyMultivariable survival analysisValvular heart diseaseRisk of deathPart D claimsMonths of lifeMinimum Data SetAnticoagulant discontinuationAnticoagulated individualsMean CHAVASc scoreCause mortalityMultivariable adjustmentOral anticoagulantsCohort study
2015
Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study
Tinetti ME, McAvay G, Trentalange M, Cohen AB, Allore HG. Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study. The BMJ 2015, 351: h4984. PMID: 26432468, PMCID: PMC4591503, DOI: 10.1136/bmj.h4984.Peer-Reviewed Original ResearchConceptsSerotonin-norepinephrine reuptake inhibitorsMultiple chronic conditionsSelective serotonin reuptake inhibitorsAdjusted hazard ratioRisk of deathCalcium channel blockersChronic conditionsHazard ratioΒ-blockersCohort studyReuptake inhibitorsAtrial fibrillationOlder adultsChannel blockersCardiovascular drugsSSRIs/serotonin-norepinephrine reuptake inhibitorsRenin-angiotensin system blockersNorepinephrine reuptake inhibitorsSerotonin reuptake inhibitorsCommon combinationRAS blockersSystem blockersStudy drugHeart failureThromboembolic disease
2012
Designing Health Care for the Most Common Chronic Condition—Multimorbidity
Tinetti ME, Fried TR, Boyd CM. Designing Health Care for the Most Common Chronic Condition—Multimorbidity. JAMA 2012, 307: 2493-2494. PMID: 22797447, PMCID: PMC4083627, DOI: 10.1001/jama.2012.5265.Peer-Reviewed Original Research
2008
Development of a Tool for Eliciting Patient Priority from Among Competing Cardiovascular Disease, Medication‐Symptoms, and Fall Injury Outcomes
Tinetti ME, McAvay GJ, Fried TR, Foody JM, Bianco L, Ginter S, Fraenkel L. Development of a Tool for Eliciting Patient Priority from Among Competing Cardiovascular Disease, Medication‐Symptoms, and Fall Injury Outcomes. Journal Of The American Geriatrics Society 2008, 56: 730-736. PMID: 18266842, PMCID: PMC3703614, DOI: 10.1111/j.1532-5415.2007.01627.x.Peer-Reviewed Original ResearchConceptsMedication symptomsFall injuriesIntraclass correlationCardiovascular disease outcomesMedication-related symptomsWilcoxon rank sum testRank sum testCVD outcomesCardiovascular diseaseDisease outcomePatient prioritiesSenior housing residentsSenior housing sitesInjury outcomesInjurySum testConvenience sampleRelative importance scores
1998
Physician Awareness of Alcohol Use Disorders Among Older Patients
Reid M, Tinetti M, Brown C, Concato J. Physician Awareness of Alcohol Use Disorders Among Older Patients. Journal Of General Internal Medicine 1998, 13: 729-734. PMID: 9824517, PMCID: PMC1497030, DOI: 10.1046/j.1525-1497.1998.00223.x.Peer-Reviewed Original ResearchConceptsAlcohol use disorderOlder patientsPrimary care physiciansInternal medicine physiciansCare physiciansPhysician awarenessMedicine physiciansUse disordersPrevalence estimatesPrimary care physicians' awarenessAnnual screening ratesQuantity-frequency questionsCross-sectional telephone surveyFamily practice physiciansGroup of physiciansCAGE questionsScreening ratesRegular screeningMiddle-aged physiciansPrevalence ratesPractice physiciansPhysician educationPatientsOlder physiciansBiochemical markersHealth Care Utilization and Costs in a Medicare Population by Fall Status
Rizzo J, Friedkin R, Williams C, Nabors J, Acampora D, Tinetti M. Health Care Utilization and Costs in a Medicare Population by Fall Status. Medical Care 1998, 36: 1174-1188. PMID: 9708590, DOI: 10.1097/00005650-199808000-00006.Peer-Reviewed Original ResearchMeSH KeywordsAccidental FallsAgedCenters for Medicare and Medicaid Services, U.S.ConnecticutFemaleFollow-Up StudiesHealth Care CostsHealth Care SurveysHealth ServicesHealth StatusHumansInjury Severity ScoreLogistic ModelsLong-Term CareMaleMedicareMultivariate AnalysisRegistriesSocioeconomic FactorsUnited StatesConceptsHealth care costsCare costsOlder personsTotal health care costsEmergency room costsHealth care utilizationSeverity of fallsAnnual hospital costsHealth Care Financing AdministrationPublic health practitionersNoninjurious fallsNursing home costsInjurious fallsCare registriesCare utilizationHospital costsFall statusMedicare populationHome healthNursing homesFall frequencyRoom costsFall severitySame time periodHealth practitioners
1993
Development of the Common Data Base for the FICSIT Trials
Buchner D, Hornbrook M, Kutner N, Tinetti M, Dry M, Mulrow C, Schechtman K, Gerety M, Fiatarone M, Wolf S, Rossiter J, Arfken C, Kanten K, Lipsitz L, Sattin R, DeNino L, Group F. Development of the Common Data Base for the FICSIT Trials. Journal Of The American Geriatrics Society 1993, 41: 297-308. PMID: 8440854, DOI: 10.1111/j.1532-5415.1993.tb06708.x.Peer-Reviewed Original Research