2012
Preventing Diabetes among Fair Haven Families: A Community-Based Approach to Quality Improvement
Chakkalakal RJ, Camp AW, Magenheimer E, Savoye M, Lubsen J, Lucas G, Rosenthal MS. Preventing Diabetes among Fair Haven Families: A Community-Based Approach to Quality Improvement. Journal Of Health Care For The Poor And Underserved 2012, 23: 247-254. PMID: 22864501, DOI: 10.1353/hpu.2012.0136.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildCommunity Health CentersCommunity-Based Participatory ResearchConnecticutDiabetes Mellitus, Type 2Evidence-Based PracticeFamilyFemaleHispanic or LatinoHumansLife StyleMedically Underserved AreaMiddle AgedObesityQuality Assurance, Health CareSocial SupportWeight Reduction ProgramsYoung AdultHepatic Fat Accumulation Is Modulated by the Interaction between the rs738409 Variant in the PNPLA3 Gene and the Dietary Omega6/Omega3 PUFA Intake
Santoro N, Savoye M, Kim G, Marotto K, Shaw MM, Pierpont B, Caprio S. Hepatic Fat Accumulation Is Modulated by the Interaction between the rs738409 Variant in the PNPLA3 Gene and the Dietary Omega6/Omega3 PUFA Intake. PLOS ONE 2012, 7: e37827. PMID: 22629460, PMCID: PMC3357343, DOI: 10.1371/journal.pone.0037827.Peer-Reviewed Original ResearchConceptsALT levelsObese youthSingle nucleotide polymorphismsRs738409 single nucleotide polymorphismFatty acid intakeFatty liver developmentLiver fat contentHepatic fat accumulationNutrition Data SystemRs738409 variantPNPLA3 genotypePUFA intakeFatty liverAcid intakeHepatic steatosisHepatic fatLiver damageDietary factorsFat accumulationPNPLA3 geneMRI studiesG alleleALT measurementsPUFA ratioPotential role
2011
Long-term Results of an Obesity Program in an Ethnically Diverse Pediatric Population
Savoye M, Nowicka P, Shaw M, Yu S, Dziura J, Chavent G, O'Malley G, Serrecchia JB, Tamborlane WV, Caprio S. Long-term Results of an Obesity Program in an Ethnically Diverse Pediatric Population. Pediatrics 2011, 127: 402-410. PMID: 21300674, PMCID: PMC3065145, DOI: 10.1542/peds.2010-0697.Peer-Reviewed Original ResearchConceptsControl groupLow-density lipoprotein cholesterolTotal body fat massIntensive lifestyle programIntensive lifestyle interventionHomeostasis model assessmentActive intervention phaseWeight management programBody fat massLong-term resultsBMI z-scorePercent body fatDiverse pediatric populationFamily-based programsLifestyle interventionLipoprotein cholesterolTotal cholesterolObese childrenObese populationPediatric populationInsulin resistanceObesity programLifestyle programFat massIntervention group
2009
Glucose dysregulation and hepatic steatosis in obese adolescents: Is there a link?
Cali AM, De Oliveira AM, Kim H, Chen S, Reyes‐Mugica M, Escalera S, Dziura J, Taksali SE, Kursawe R, Shaw M, Savoye M, Pierpont B, Constable RT, Caprio S. Glucose dysregulation and hepatic steatosis in obese adolescents: Is there a link? Hepatology 2009, 49: 1896-1903. PMID: 19434725, PMCID: PMC2692562, DOI: 10.1002/hep.22858.Peer-Reviewed Original ResearchConceptsHepatic fat fractionObese adolescentsHepatic fat contentGlucose dysregulationHepatic steatosisMetabolic syndromeFatty liverInsulin sensitivityTotal fatHigher hepatic fat fractionStandard oral glucose tolerance testOral glucose tolerance testTwo-hour plasma glucoseSubcutaneous fat ratioHomeostasis model assessmentAbdominal fat distributionGlucose tolerance testProinflammatory milieuHMW adiponectinIL-6Insulin resistanceMatsuda indexTolerance testPlasma glucoseFat distribution