2024
Lung infections due to emerging fungal pathogens
Roman F, Pischel L, Azar M. Lung infections due to emerging fungal pathogens. Current Opinion In Pulmonary Medicine 2024, 30: 258-265. PMID: 38411158, DOI: 10.1097/mcp.0000000000001059.Peer-Reviewed Original ResearchConceptsEndemic mycosesManagement of pulmonary infectionsFungal pathogensPathogenic fungiAntifungal prophylaxisBlastomyces speciesFungal infectionsFungal organismsAspergillus moldsEnvironmental changesImmunocompromised hostsPulmonary infectionTherapeutic challengeLung infectionMycosesClinical evidenceClinical managementIncreased incidencePulmonary diseaseEnlarged poolDisease burdenInfectionLomentosporaScedosporiumDiagnostic capabilities
2021
Increased Detection of Mycobacterium tuberculosis Disease Using a Tissue-Based Laboratory-Developed Polymerase Chain Reaction Assay Compared to Standard Diagnostics.
Mackow NA, Abi-Raad R, Kerantzas CA, Hui P, Malinis M, Azar MM. Increased Detection of Mycobacterium tuberculosis Disease Using a Tissue-Based Laboratory-Developed Polymerase Chain Reaction Assay Compared to Standard Diagnostics. American Journal Of Tropical Medicine And Hygiene 2021, 105: 1657-1661. PMID: 34544041, PMCID: PMC8641361, DOI: 10.4269/ajtmh.21-0104.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCulture TechniquesFemaleHumansLungLymph NodesMaleMiddle AgedMycobacterium tuberculosisPleuraReal-Time Polymerase Chain ReactionReference StandardsRetrospective StudiesSensitivity and SpecificitySputumTuberculosisTuberculosis, Lymph NodeTuberculosis, Multidrug-ResistantTuberculosis, PleuralTuberculosis, PulmonaryConceptsComposite reference standardMTB PCRAFB cultureMycobacterium tuberculosisPolymerase chain reactionAcid-fast bacilli smearMycobacterium tuberculosis diseasePositive AFB cultureChain reactionReal-time polymerase chain reactionStandard diagnosticsBacilli smearMTB casesTuberculosis diseaseClinical sensitivityLong turnaround timeXpertClinical performanceReference standardPCRVariable sensitivityTurnaround timeLymphPatientsTuberculosisCOVID‐19 in hospitalized lung and non‐lung solid organ transplant recipients: A comparative analysis from a multicenter study
Heldman MR, Kates OS, Safa K, Kotton CN, Georgia SJ, Steinbrink JM, Alexander BD, Hemmersbach‐Miller M, Blumberg EA, Crespo MM, Multani A, Lewis AV, Beaird O, Haydel B, La Hoz RM, Moni L, Condor Y, Flores S, Munoz CG, Guitierrez J, Diaz EI, Diaz D, Vianna R, Guerra G, Loebe M, Rakita RM, Malinis M, Azar MM, Hemmige V, McCort ME, Chaudhry ZS, Singh P, Hughes K, Velioglu A, Yabu JM, Morillis JA, Mehta SA, Tanna SD, Ison MG, Tomic R, Derenge A, van Duin D, Maximin A, Gilbert C, Goldman JD, Sehgal S, Weisshaar D, Girgis RE, Nelson J, Lease ED, Limaye AP, Fisher CE, Team T. COVID‐19 in hospitalized lung and non‐lung solid organ transplant recipients: A comparative analysis from a multicenter study. American Journal Of Transplantation 2021, 21: 2774-2784. PMID: 34008917, PMCID: PMC9215359, DOI: 10.1111/ajt.16692.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsLung transplant recipientsOrgan transplant recipientsTransplant recipientsRisk factorsAllograft dysfunctionAdult solid organ transplant recipientsCOVID-19High mortalityChronic lung allograft dysfunctionOnly independent risk factorMultivariable logistic regression modelChronic allograft dysfunctionComorbidity-adjusted mortalityLung allograft dysfunctionMulticenter cohort studyIndependent risk factorCoronavirus disease 2019Logistic regression modelsLung transplantCohort studyHeart failureMulticenter studyDisease 2019Mortality
2020
Case 2-2020: A 64-Year-Old Man with Fever and Respiratory Failure
Azar MM, Muse VV, Villalba JA, Turbett SE. Case 2-2020: A 64-Year-Old Man with Fever and Respiratory Failure. New England Journal Of Medicine 2020, 382: 276-285. PMID: 31940703, DOI: 10.1056/nejmcpc1913468.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisBronchoalveolar Lavage FluidCoccidioidomycosisDiagnosis, DifferentialFatal OutcomeFeverGlomerulonephritisHeart FailureHumansLungLung Diseases, FungalMaleMiddle AgedMyocardiumPneumoniaRadiography, ThoracicRespiratory Insufficiency
2018
Case 1-2018: A 39-Year-Old Woman with Rapidly Progressive Respiratory Failure
Hibbert KA, Shepard JO, Lane RJ, Azar MM. Case 1-2018: A 39-Year-Old Woman with Rapidly Progressive Respiratory Failure. New England Journal Of Medicine 2018, 378: 182-190. PMID: 29320657, DOI: 10.1056/nejmcpc1712222.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAdenoviridaeAdenoviridae InfectionsAdultAntiviral AgentsCidofovirCytosineDiagnosis, DifferentialFemaleHumansImmunocompromised HostLeukemia, Myeloid, AcuteLungNasopharynxOpportunistic InfectionsOrganophosphonatesRadiography, ThoracicRenal InsufficiencyRespiratory InsufficiencyStem Cell TransplantationTomography, X-Ray ComputedViral Load
2017
Case 30-2017
Bhattacharyya RP, Flores EJ, Azar MM. Case 30-2017. New England Journal Of Medicine 2017, 377: 1274-1282. PMID: 28953442, DOI: 10.1056/nejmcpc1706100.Peer-Reviewed Case Reports and Technical NotesCase 26-2017
Letourneau AR, Price MC, Azar MM. Case 26-2017. New England Journal Of Medicine 2017, 377: 770-778. PMID: 28834480, DOI: 10.1056/nejmcpc1616402.Peer-Reviewed Case Reports and Technical Notes
2015
Histoplasmosis: Up-to-Date Evidence-Based Approach to Diagnosis and Management
Hage CA, Azar MM, Bahr N, Loyd J, Wheat LJ. Histoplasmosis: Up-to-Date Evidence-Based Approach to Diagnosis and Management. Seminars In Respiratory And Critical Care Medicine 2015, 36: 729-745. PMID: 26398539, DOI: 10.1055/s-0035-1562899.BooksConceptsMost patientsPulmonary diseaseAcute pulmonary diseaseChronic cavitary pneumoniaCommon endemic mycosisProgressive disseminated diseaseCommon clinical presentationCommunity-acquired pneumoniaChronic pulmonary diseaseEvaluation of patientsLiposomal amphotericin BDate evidence-based approachGranulomatous inflammatory diseaseDiagnosis of histoplasmosisEvidence-based approachMediastinal manifestationsCavitary pneumoniaDisseminated diseaseClinical presentationCrohn's diseasePreferred agentClinical syndromeAnaerobic infectionsInflammatory diseasesEndemic mycosis