2021
Nucleic Acid–based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline
Evans SE, Jennerich AL, Azar MM, Cao B, Crothers K, Dickson RP, Herold S, Jain S, Madhavan A, Metersky ML, Myers LC, Oren E, Restrepo MI, Semret M, Sheshadri A, Wunderink RG, Dela Cruz CS. Nucleic Acid–based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline. American Journal Of Respiratory And Critical Care Medicine 2021, 203: 1070-1087. PMID: 33929301, PMCID: PMC8314899, DOI: 10.1164/rccm.202102-0498st.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaNucleic acid-based testingClinical practice guidelinesRespiratory samplesPractice guidelinesViral pathogensOfficial American Thoracic Society Clinical Practice GuidelineAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionEvidence-based clinical practice guidelinesSyndrome coronavirus 2 infectionAntibiotic use patternsCoronavirus 2 infectionGrading of RecommendationsRisk of biasOverall survivalPragmatic systematic reviewClinical recommendationsMultidisciplinary panelDiagnostic utilityEvidence reviewPopulation interventionsSystematic reviewInfluenzaRoutine diagnostics
2020
Added Diagnostic Utility of Clinical Metagenomics for the Diagnosis of Pneumonia in Immunocompromised Adults
Azar MM, Schlaberg R, Malinis MF, Bermejo S, Schwarz T, Xie H, Dela Cruz CS. Added Diagnostic Utility of Clinical Metagenomics for the Diagnosis of Pneumonia in Immunocompromised Adults. CHEST Journal 2020, 159: 1356-1371. PMID: 33217418, DOI: 10.1016/j.chest.2020.11.008.Peer-Reviewed Original ResearchConceptsFinal clinical diagnosisDiagnostic yieldFungal pneumoniaImmunocompromised adultsMicrobiologic diagnosisAntimicrobial stewardshipMicrobiologic testingClinical diagnosisClinical metagenomicsCommunity-acquired pneumoniaStandard of careDiagnosis of pneumoniaAdult patientsRadiologic findingsBacterial pneumoniaBAL fluidProspective studyViral pneumoniaBacterial causePneumoniaDiagnostic utilityStudy designDiagnosisAdultsHypothetical impactEndemic Fungi Presenting as Community-Acquired Pneumonia: A Review
Azar MM, Malo J, Hage CA. Endemic Fungi Presenting as Community-Acquired Pneumonia: A Review. Seminars In Respiratory And Critical Care Medicine 2020, 41: 522-537. PMID: 32629490, DOI: 10.1055/s-0040-1702194.Peer-Reviewed Original ResearchMeSH KeywordsBlastomycosisCoccidioidomycosisCommunity-Acquired InfectionsHistoplasmosisHumansLung Diseases, FungalPneumoniaConceptsCommunity-acquired pneumoniaCommon bacterial causeAreas of endemicityDimorphic fungal infectionsRespiratory manifestationsClinical presentationPulmonary histoplasmosisTreatment strategiesDiagnostic modalitiesBacterial causeEndemic areasFungal infectionsPneumoniaHistoplasma capsulatumHistoplasmosisCoccidioides posadasiiBlastomycosisCoccidioidomycosisEpidemiologyDimorphic fungusPresentingReviewPathogenesisInfectionDiagnosis