2024
Clinical outcomes of baloxavir versus oseltamivir in immunocompromised patients
Ringer M, Malinis M, McManus D, Davis M, Shah S, Trubin P, Topal J, Azar M. Clinical outcomes of baloxavir versus oseltamivir in immunocompromised patients. Transplant Infectious Disease 2024, 26: e14249. PMID: 38319665, DOI: 10.1111/tid.14249.Peer-Reviewed Original ResearchLength of stayIntensive care unitBaloxavir groupClinical outcomesSecondary outcomesIntensive care unit length of stayRetrospective study of hospitalized patientsEfficacy of baloxavirResolution of feverImmunocompromised adult patientsStudy of hospitalized patientsRetrospective cohort studyAssociated with longer timeResolution of hypoxiaOseltamivir groupInfluenza subtypesImmunocompromised patientsInfluenza ANo significant differenceMedian timeResistance ratesNeuraminidase inhibitorsRetrospective studyBaseline characteristicsAdult patients
2022
Rectal screening for azole non‐susceptible Candida species in patients undergoing liver transplantation
Radcliffe C, Patel KK, Azar MM, Koff A, Belfield KD, Peaper DR, Topal JE, Malinis M. Rectal screening for azole non‐susceptible Candida species in patients undergoing liver transplantation. Transplant Infectious Disease 2022, 24: e13811. PMID: 35184347, DOI: 10.1111/tid.13811.Peer-Reviewed Original ResearchConceptsAppropriate antifungal prophylaxisAntifungal prophylaxisRisk factorsTransplant recipientsRectal swabsSolid organ transplant recipientsCommon invasive fungal infectionYale-New Haven HospitalDays of LTTime of LTLiver transplant recipientsOrgan transplant recipientsRetrospective chart reviewMore risk factorsMultiple risk factorsInvasive fungal infectionsNew Haven HospitalPrimary LTLiver transplantationAdult patientsChart reviewLT candidatesRectal screeningCandida infectionsMedian number
2020
Added Diagnostic Utility of Clinical Metagenomics for the Diagnosis of Pneumonia in Immunocompromised Adults
Azar MM, Schlaberg R, Malinis MF, Bermejo S, Schwarz T, Xie H, Dela Cruz CS. Added Diagnostic Utility of Clinical Metagenomics for the Diagnosis of Pneumonia in Immunocompromised Adults. CHEST Journal 2020, 159: 1356-1371. PMID: 33217418, DOI: 10.1016/j.chest.2020.11.008.Peer-Reviewed Original ResearchConceptsFinal clinical diagnosisDiagnostic yieldFungal pneumoniaImmunocompromised adultsMicrobiologic diagnosisAntimicrobial stewardshipMicrobiologic testingClinical diagnosisClinical metagenomicsCommunity-acquired pneumoniaStandard of careDiagnosis of pneumoniaAdult patientsRadiologic findingsBacterial pneumoniaBAL fluidProspective studyViral pneumoniaBacterial causePneumoniaDiagnostic utilityStudy designDiagnosisAdultsHypothetical impact