2024
Noninvasive in vivo photoacoustic detection of malaria with Cytophone in Cameroon
Yadem A, Armstrong J, Sarimollaoglu M, Kiki Massa C, Ndifo J, Menyaev Y, Mbe A, Richards K, Wade M, Zeng Y, Chen R, Zhou Q, Meten E, Ntone R, Tchuedji Y, Ullah S, Galanzha E, Eteki L, Gonsu H, Biris A, Suen J, Boum Y, Zharov V, Parikh S. Noninvasive in vivo photoacoustic detection of malaria with Cytophone in Cameroon. Nature Communications 2024, 15: 9228. PMID: 39455558, PMCID: PMC11511992, DOI: 10.1038/s41467-024-53243-z.Peer-Reviewed Original ResearchConceptsClearance of parasitemiaDetection of malariaMalaria-infected red blood cellsDiagnosed symptomatic casesCross-sectional cohortUncomplicated malariaMalaria diagnosticsMalaria infectionRed blood cellsSymptomatic casesTarget antigenAsymptomatic reservoirCameroonian adultsFlow cytometer platformBlood samplesReservoir of infectionBlood cellsLack sensitivityLongitudinal cohortMolecular assaysMalariaIRBCPoint-of-careCohortQuantitative PCR
2020
Investigating selected host and parasite factors potentially impacting upon seasonal malaria chemoprevention in Bama, Burkina Faso
Somé FA, Bazié T, Ehrlich HY, Goodwin J, Lehane A, Neya C, Zachari K, Wade M, Ouattara JM, Foy BD, Dabiré RK, Parikh S, Ouédraogo JB. Investigating selected host and parasite factors potentially impacting upon seasonal malaria chemoprevention in Bama, Burkina Faso. Malaria Journal 2020, 19: 238. PMID: 32631416, PMCID: PMC7339464, DOI: 10.1186/s12936-020-03311-8.Peer-Reviewed Original ResearchConceptsSeasonal malaria chemopreventionDay 7 concentrationsSMC administrationMalaria chemopreventionMalaria infectionDay 7 plasma concentrationsHigh malaria transmission seasonBlood spotsFirst monthPfcrt 76TPrevalence of microscopicSubmicroscopic malaria infectionMalaria transmission seasonPlasmodium falciparum infectionPfcrt K76THigh transmission settingsSequential cross-sectional surveysCross-sectional surveyNon-significant trendAmodiaquine metabolismPfmdr1 N86Malaria parasitaemiaFalciparum infectionK76TPlasma concentrations