2000
Of mice and men: Dissecting the genetic pathway that controls left‐right asymmetry in mice and humans
Schneider H, Brueckner M. Of mice and men: Dissecting the genetic pathway that controls left‐right asymmetry in mice and humans. American Journal Of Medical Genetics 2000, 97: 258-270. PMID: 11376437, DOI: 10.1002/1096-8628(200024)97:4<258::aid-ajmg1276>3.0.co;2-8.Peer-Reviewed Original ResearchMeSH KeywordsAbnormalities, MultipleAnimalsBody PatterningCiliaDyneinsEctodermEmbryonic and Fetal DevelopmentEndodermFetal ProteinsGastrulaGene Expression Regulation, DevelopmentalGenesGenes, HomeoboxGenes, LethalHomeodomain ProteinsHumansKinesinsMiceMice, Mutant StrainsMutationNotochordPhenotypeSpecies SpecificityTranscription FactorsConceptsLeft-right asymmetrySpontaneous mouse mutationGenetic pathwaysHuman homologueMouse mutationNode monociliaHuman mutationsHuman phenotypesFinal phenotypeOrchestrated mannerPathways resultsMouse phenotypeGenesLaterality determinationMutationsPhenotypeModel systemDifferent stepsMonociliaHomologuesCombination of analysisMicePathwayHuman developmentInitial asymmetry
1996
The genetics of left-right development and heterotaxia
Bowers P, Brueckner M, Yost H. The genetics of left-right development and heterotaxia. Seminars In Perinatology 1996, 20: 577-588. PMID: 9090782, DOI: 10.1016/s0146-0005(96)80070-x.Peer-Reviewed Original ResearchConceptsLeft-right developmentMolecular genetic mechanismsPrimitive heart tubeSingle geneCardiac morphogenesisDifferent genesCardiac loopingHeart tubeGenesPhenotypeComplex groupHeterotaxiaMorphogenesisMost crucial stepCrucial stepGeneticsElucidationLoopingWide spectrumDevelopment resultsCongenital heart