1997
Mutation of an axonemal dynein affects left–right asymmetry in inversus viscerum mice
Supp D, Witte D, Potter S, Brueckner M. Mutation of an axonemal dynein affects left–right asymmetry in inversus viscerum mice. Nature 1997, 389: 963-966. PMID: 9353118, PMCID: PMC1800588, DOI: 10.1038/40140.Peer-Reviewed Original ResearchConceptsAxonemal dynein heavy chain geneDynein heavy chain geneAsymmetric expression patternMicrotubule-based motorsEmbryonic day 7.5Vertebrate patterningLeft-right axisGenetic hierarchyLeft-right asymmetryEarly molecular mechanismsPositional cloningHeavy chain geneInversus viscerum (iv) mouseGene productsVisceral asymmetryAxonemal dyneinsSymmetrical embryosExpression patternsMolecular mechanismsLR determinationMolecular levelDay 7.5EmbryosLateralization defectsDynein
1996
Laterality disturbances
Bowers P, Brueckner M, Yost H. Laterality disturbances. Progress In Pediatric Cardiology 1996, 6: 53-62. DOI: 10.1016/1058-9813(96)00171-3.Peer-Reviewed Original ResearchLeft-right body axisBody axisEmbryonic left-right axisPrimitive heart tubeLeft-right axisLeft-right asymmetryCardiac morphogenesisHeart developmentDevelopmental processesDorsoventral axesGenetic stepsHeart tubeMolecular levelLoop formationLaterality disturbancesComplex groupMorphogenesisFormation resultsVisible asymmetry