Defective Suppressor Function of Human CD4+ CD25+ Regulatory T Cells in Autoimmune Polyglandular Syndrome Type II
Kriegel MA, Lohmann T, Gabler C, Blank N, Kalden JR, Lorenz HM. Defective Suppressor Function of Human CD4+ CD25+ Regulatory T Cells in Autoimmune Polyglandular Syndrome Type II. Journal Of Experimental Medicine 2004, 199: 1285-1291. PMID: 15117972, PMCID: PMC2211900, DOI: 10.1084/jem.20032158.Peer-Reviewed Original ResearchConceptsAutoimmune polyglandular syndromeRegulatory T cellsAPS IIT cellsAutoimmune polyglandular syndrome type IIOrgan-specific autoimmune diseasesAPS type IAPS type IIDefective suppressor functionNormal healthy donorsImportant surface markerPolyglandular syndromeAutoimmune endocrinopathiesControl patientsMultiple endocrinopathiesAutoimmune diseasesPeripheral bloodSuppressive capacityType IIHealthy donorsHuman autoimmunityCentral toleranceHuman CD4Murine modelSurface markers