2013
Bupropion for overweight women with binge-eating disorder: a randomized, double-blind, placebo-controlled trial.
White MA, Grilo CM. Bupropion for overweight women with binge-eating disorder: a randomized, double-blind, placebo-controlled trial. The Journal Of Clinical Psychiatry 2013, 74: 400-6. PMID: 23656848, PMCID: PMC4021866, DOI: 10.4088/jcp.12m08071.Peer-Reviewed Original ResearchConceptsBinge-eating disorderPlacebo-controlled trialObese womenOutcome measuresWeight lossDSM-IV-TR research criteriaTreatment of BEDInappropriate weight compensatory behaviorsRandomized placebo-controlled trialShort-term weight lossFood cravingsPercent BMI lossSecondary outcome measuresPrimary outcome measureShort-term efficacyTerm weight lossBinge-eating frequencySignificant time effectStand-alone treatmentLong-term trialsBMI lossPlacebo groupLifestyle interventionOverweight womenRandomized participants
2010
Low-dose naltrexone augmentation of nicotine replacement for smoking cessation with reduced weight gain: A randomized trial
Toll BA, White M, Wu R, Meandzija B, Jatlow P, Makuch R, O’Malley S. Low-dose naltrexone augmentation of nicotine replacement for smoking cessation with reduced weight gain: A randomized trial. Drug And Alcohol Dependence 2010, 111: 200-206. PMID: 20542391, PMCID: PMC3771701, DOI: 10.1016/j.drugalcdep.2010.04.015.Peer-Reviewed Original ResearchConceptsWeight gainSmoking cessationPoint prevalence smoking abstinence ratePre-specified primary outcomesLow-dose naltrexoneOpen-label therapySmoking abstinence ratesPoint prevalence abstinenceReduced weight gainNaltrexone augmentationPlacebo groupNicotine replacementPrimary outcomeQuit dateAbstinence ratesLabel therapyNicotine patchBehavioral counselingNaltrexoneAbstinent participantsSmokersWeight concernsWeeksCessationLower rates