1999
Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*
Mamula M, Gee R, Elliott J, Sette A, Southwood S, Jones P, Blier P. Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*. Journal Of Biological Chemistry 1999, 274: 22321-22327. PMID: 10428801, DOI: 10.1074/jbc.274.32.22321.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAspartic AcidAutoantibodiesAutoimmunityB-LymphocytesBinding, CompetitiveCytochrome c GroupHistocompatibility Antigens Class IIImmune ToleranceIsomerismLymphocyte ActivationMiceMice, Inbred MRL lprMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProtein BindingProtein Processing, Post-TranslationalRibonucleoproteins, Small NuclearT-LymphocytesConceptsSystemic lupus erythematosusAutoimmune responseT cell autoimmune responsesHuman systemic lupus erythematosusInitiation of autoimmunityT cell compartmentT cell responsesImmunization of miceFunctioning immune systemLupus erythematosusSelf antigensAutoimmune diseasesImmunologic stimuliC-peptidePeptide autoantigensImmune systemCell responsesForeign pathogensImmunizationCytochrome c peptideMiceCell compartmentPresent studyPeptidesResponse
1997
B Lymphocytes as Autoantigen‐presenting Cells in the Amplification of Autoimmunitya
ROTH R, GEE R, MAMULA M. B Lymphocytes as Autoantigen‐presenting Cells in the Amplification of Autoimmunitya. Annals Of The New York Academy Of Sciences 1997, 815: 88-100. PMID: 9186642, DOI: 10.1111/j.1749-6632.1997.tb52047.x.Peer-Reviewed Original ResearchConceptsB cell-deficient miceCell-deficient miceNaive T cellsT cellsSelf antigensIL-4IL-5B cellsB7-2 costimulatory moleculesAutoantigen-presenting cellsAutoreactive T cellsT cell toleranceAntigen-presenting cellsCytokine mRNA responsesB cell subsetsNaive lymphAutoimmune responseCell subsetsCostimulatory moleculesAntigen presentationCytokine mRNAIFN-gammaB lymphocytesCell toleranceMRNA response
1996
B7 costimulation and autoantigen specificity enable B cells to activate autoreactive T cells.
Roth R, Nakamura T, Mamula M. B7 costimulation and autoantigen specificity enable B cells to activate autoreactive T cells. The Journal Of Immunology 1996, 157: 2924-31. PMID: 8816398, DOI: 10.4049/jimmunol.157.7.2924.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAntibodies, MonoclonalAntigen PresentationAntigens, CDAutoantigensAutoimmunityB7-1 AntigenB7-2 AntigenBase SequenceB-LymphocytesCell MovementCytochrome c GroupCytokinesFemaleGene Expression RegulationImmunizationLymph NodesLymphocyte ActivationMembrane GlycoproteinsMiceMolecular Sequence DataPeptide FragmentsPolymerase Chain ReactionRatsRNA, MessengerSelf ToleranceSignal TransductionT-Lymphocyte SubsetsConceptsAutoreactive T cellsT cell responsesT cellsB cellsIL-4IL-5Self-AgImmunized B-cell-deficient miceCell responsesAutoimmune T cell responsesB cell-deficient miceB7-1 costimulatory moleculeT cell autoimmunityCell-deficient miceTreatment of miceT cell toleranceNaive T cellsCytokine mRNA responsesCell autoimmunityB7 costimulationCostimulatory moleculesAutoantigen specificityB7-2Cytokine mRNAIFN-gamma
1992
Anti-Ro autoantibody with cross-reactive binding to the heavy chain of immunoglobulin G.
Mamula M, Harley J. Anti-Ro autoantibody with cross-reactive binding to the heavy chain of immunoglobulin G. The Yale Journal Of Biology And Medicine 1992, 65: 277-87. PMID: 1290272, PMCID: PMC2589586.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAutoantigensBinding, CompetitiveCattleCross ReactionsCyanogen BromideEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin Fab FragmentsImmunoglobulin Fc FragmentsImmunoglobulin GImmunoglobulin Heavy ChainsLupus Erythematosus, SystemicPeptide FragmentsPrecipitin TestsRabbitsRibonucleoproteinsRNA, Small CytoplasmicConceptsSystemic lupus erythematosusRo antibodiesAutoimmune diseasesCross-reactive bindingSera of patientsAnti-Ro autoantibodiesHeavy chainAnti-Ro seraFragments of IgGRo proteinLupus erythematosusCyanogen bromide digestion fragmentsAntigenic stimulusRo seraPatient seraAutoantibodiesIgGFine specificityImmunologic determinantsRo responseImmunoglobulin GSerumAntibodiesRo particleRabbit serum
1990
The specificity of human anti-cytochrome c autoantibodies that arise in autoimmune disease.
Mamula M, Jemmerson R, Hardin J. The specificity of human anti-cytochrome c autoantibodies that arise in autoimmune disease. The Journal Of Immunology 1990, 144: 1835-40. PMID: 1689756, DOI: 10.4049/jimmunol.144.5.1835.Peer-Reviewed Original ResearchConceptsC autoantibodiesC antibodyPresence of autoantibodiesConnective tissue diseaseSpecificity of autoantibodiesAntimitochondrial antibodiesAutoantibody responseTissue diseaseAutoimmune diseasesDisease subsetsSm autoantigenPatient seraAutoantibodiesAnimal modelsModel AgAntibodiesDiseaseSpecificityPatientsSLEAutoantigensMicePathologySerumResponse