1998
Autoreactive B Cell Regulation: Peripheral Induction of Developmental Arrest by Lupus-Associated Autoantigens
Santulli-Marotto S, Retter M, Gee R, Mamula M, Clarke S. Autoreactive B Cell Regulation: Peripheral Induction of Developmental Arrest by Lupus-Associated Autoantigens. Immunity 1998, 8: 209-219. PMID: 9492002, DOI: 10.1016/s1074-7613(00)80473-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantigensB-LymphocytesBone MarrowCell DifferentiationDNA, Single-StrandedEnzyme-Linked Immunosorbent AssayFluorescent Antibody TechniqueGene Rearrangement, B-Lymphocyte, Heavy ChainHematopoietic Stem CellsHybridomasImmune ToleranceLupus Erythematosus, SystemicLymphocyte ActivationMiceMice, Inbred MRL lprMice, TransgenicRibonucleoproteins, Small NuclearSnRNP Core ProteinsSpleenConceptsB cellsAnti-Sm B cellsAnti-ssDNA antibodiesB-cell phenotypeImmature B-cell phenotypeImmature B cellsAutoreactive cellsMurine lupusPeripheral inductionTolerance inductionVH-D-JH rearrangementsTransgenic miceAnti-Sm hybridomasSplenic repertoireCell phenotypeSpontaneous activationCellsInductionLupusImmunizationAutoantigensLater stagesDevelopmental arrestMiceSecretion
1992
Anti-Ro autoantibody with cross-reactive binding to the heavy chain of immunoglobulin G.
Mamula M, Harley J. Anti-Ro autoantibody with cross-reactive binding to the heavy chain of immunoglobulin G. The Yale Journal Of Biology And Medicine 1992, 65: 277-87. PMID: 1290272, PMCID: PMC2589586.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAutoantigensBinding, CompetitiveCattleCross ReactionsCyanogen BromideEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin Fab FragmentsImmunoglobulin Fc FragmentsImmunoglobulin GImmunoglobulin Heavy ChainsLupus Erythematosus, SystemicPeptide FragmentsPrecipitin TestsRabbitsRibonucleoproteinsRNA, Small CytoplasmicConceptsSystemic lupus erythematosusRo antibodiesAutoimmune diseasesCross-reactive bindingSera of patientsAnti-Ro autoantibodiesHeavy chainAnti-Ro seraFragments of IgGRo proteinLupus erythematosusCyanogen bromide digestion fragmentsAntigenic stimulusRo seraPatient seraAutoantibodiesIgGFine specificityImmunologic determinantsRo responseImmunoglobulin GSerumAntibodiesRo particleRabbit serum
1987
Implications of anti-Ro/Sjögren's syndrome A antigen autoantibody in normal sera for autoimmunity.
Gaither K, Fox O, Yamagata H, Mamula M, Reichlin M, Harley J. Implications of anti-Ro/Sjögren's syndrome A antigen autoantibody in normal sera for autoimmunity. Journal Of Clinical Investigation 1987, 79: 841-846. PMID: 3546381, PMCID: PMC424215, DOI: 10.1172/jci112892.Peer-Reviewed Original ResearchConceptsRo/SSAAnti-Ro/SSALa/SSBNormal serumAntigen autoantibodiesSjögren's syndromeAnti-Ro/Sjögren's syndromeRo/Sjögren's syndromeHealthy normal donorsSjögren's syndrome autoantibodiesPreexisting immune responseRo/SSA precipitinsTrue autoantibodiesImmune responseNormal donorsAutoantibodiesSyndromeFragments of IgG.Western immunoblotSSA levelsSerumPatientsSensitive assayLow levelsAutoimmunity
1986
The Ro/SSA autoantigen as an immunogen. Some anti-Ro/SSA antibody binds IgG.
Mamula M, Fox O, Yamagata H, Harley J. The Ro/SSA autoantigen as an immunogen. Some anti-Ro/SSA antibody binds IgG. Journal Of Experimental Medicine 1986, 164: 1889-1901. PMID: 3097237, PMCID: PMC2188496, DOI: 10.1084/jem.164.6.1889.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantigensCattleEnzyme-Linked Immunosorbent AssayHumansImmune SeraImmunodiffusionImmunoglobulin Fab FragmentsImmunoglobulin GRibonucleoproteinsRNA, Small Cytoplasmic