Isoaspartyl Posttranslational Modification In Drug‐Induced Lupus
Yang M, Mamula M. Isoaspartyl Posttranslational Modification In Drug‐Induced Lupus. The FASEB Journal 2008, 22: 668.20-668.20. DOI: 10.1096/fasebj.22.1_supplement.668.20.Peer-Reviewed Original ResearchLupus-inducing drugsDrug-induced lupusT cell hyperproliferationMRL miceCell hyperproliferationOnset of autoantibodiesLupus-prone miceProtein L-isoaspartyl methyltransferaseT cell functionDose-dependent mannerERK 1/2 pathwayAutoimmune responseMultiple sclerosisRheumatoid arthritisLymphocyte functionMurine modelSelf proteinsLupusCell functionMiceDrugsHydralazineIntracellular levelsSpontaneous eventsHyperproliferation