2021
Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis, and rheumatoid arthritis
Szymczak F, Colli M, Mamula M, Evans-Molina C, Eizirik D. Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis, and rheumatoid arthritis. Science Advances 2021, 7: eabd7600. PMID: 33523973, PMCID: PMC7787485, DOI: 10.1126/sciadv.abd7600.Peer-Reviewed Original ResearchConceptsType 1 diabetesLupus erythematosusTarget tissuesRheumatoid arthritisMultiple sclerosisAutoimmune diseasesImmune systemSystemic lupus erythematosusTarget tissue levelRepurposing of drugsDisease-specific signaturesGene expression signaturesImmune assaultSimilar molecular signaturesClinical useTissue levelsDiseaseHigh expressionExpression signaturesDifferent diseasesErythematosusArthritisSclerosisDiabetesTherapy
2014
Isoaspartyl modification of ZAP70 signaling molecule alters T cell responses (555.9)
Yang M, Clarke S, Mamula M. Isoaspartyl modification of ZAP70 signaling molecule alters T cell responses (555.9). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.555.9.Peer-Reviewed Original ResearchSystemic lupus erythematosusT cell responsesCell responsesT cell immune responsesCell immune responsesAutoreactive immune cellsT cell defectsMajor target organT-cell immunodeficiencyT cell hyperproliferationPIMT-deficient miceProtein L-isoaspartyl methyltransferaseLupus pathologyAutoimmune miceLupus erythematosusImmune toleranceImmune cellsDeficient miceCell immunodeficiencyImmune responseTarget organsT cell signalingImmune systemAutoimmune BCell hyperproliferation
2011
Chapter 8 B-Lymphocyte Biology in SLE
Mamula M. Chapter 8 B-Lymphocyte Biology in SLE. 2011, 143-161. DOI: 10.1016/b978-0-12-374994-9.10008-7.Peer-Reviewed Original ResearchSystemic lupus erythematosusHuman systemic lupus erythematosusAntigen-presenting cellsB cellsDiagnostic hallmarkAutoreactive B cell responsesB-cell-specific therapiesClinical systemic lupus erythematosusB lymphocyte subsetsIgG class autoantibodiesB cell responsesT lymphocyte interactionsMultiple cellular abnormalitiesDendritic cellsLupus erythematosusAutoantibody responseLupus autoantigensClass autoantibodiesT cellsMurine modelB lymphocyte biologyGenetic predispositionReceptor inductionPathologic processesTissue pathology
2001
From T to B and back again: positive feedback in systemic autoimmune disease
Shlomchik M, Craft J, Mamula M. From T to B and back again: positive feedback in systemic autoimmune disease. Nature Reviews Immunology 2001, 1: 147-153. PMID: 11905822, DOI: 10.1038/35100573.Peer-Reviewed Original ResearchConceptsSystemic autoimmune diseaseAutoimmune diseasesPrototypical systemic autoimmune diseaseSystemic lupus erythematosusPerpetuation of autoimmunityLoss of toleranceAutoantigen targetsLupus erythematosusAutoimmune stateB cellsImmune systemNuclear autoantigensDiseaseErythematosusAutoimmunityAutoantigensLupus autoantigens: Their origins, forms, and presentation
Doyle H, Yan J, Liang B, Mamula M. Lupus autoantigens: Their origins, forms, and presentation. Immunologic Research 2001, 24: 131-147. PMID: 11594452, DOI: 10.1385/ir:24:2:131.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusMaintenance of autoimmunityT cell compartmentCentral lymphoid organsT cell developmentAutoimmune processLupus erythematosusAntigenic sinAutoreactive cellsAutoimmune diseasesLymphoid organsPresenting cellsB lymphocytesImmune systemAutoimmunityCell compartmentNumber of mechanismsCell developmentInductionErythematosusCellsLupusForeign proteinsLymphocytesCostimulation
2000
Autoantibody Responses and Pathology Regulated by B7-1 and B7-2 Costimulation in MRL/lpr Lupus
Liang B, Kashgarian M, Sharpe A, Mamula M. Autoantibody Responses and Pathology Regulated by B7-1 and B7-2 Costimulation in MRL/lpr Lupus. The Journal Of Immunology 2000, 165: 3436-3443. PMID: 10975864, DOI: 10.4049/jimmunol.165.6.3436.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAntigens, CDAntigens, Differentiation, B-LymphocyteAutoantibodiesB7-1 AntigenB7-2 AntigenBiomarkersComplement C3DNAImmunoglobulin GImmunoglobulin IsotypesImmunoglobulin MKidneyLupus NephritisLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred MRL lprMice, KnockoutRibonucleoproteins, Small NuclearT-LymphocytesConceptsMRL-lpr/lpr miceSystemic lupus erythematosusLpr miceB7-2 costimulationB7-1Autoantibody responseB7-2Murine modelCostimulatory signalsAnti-small nuclear ribonucleoproteinMRL/lpr lupusHuman systemic lupus erythematosusB7-1/B7C3 complement depositionAnti-DNA titersAnti-DNA autoantibodiesWild-type animalsImmunotherapeutic interventionsMemory CD4Lupus erythematosusAutoimmune diseasesAutoimmune pathologyC3 depositsComplement depositionT lymphocytes
1999
Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*
Mamula M, Gee R, Elliott J, Sette A, Southwood S, Jones P, Blier P. Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*. Journal Of Biological Chemistry 1999, 274: 22321-22327. PMID: 10428801, DOI: 10.1074/jbc.274.32.22321.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAspartic AcidAutoantibodiesAutoimmunityB-LymphocytesBinding, CompetitiveCytochrome c GroupHistocompatibility Antigens Class IIImmune ToleranceIsomerismLymphocyte ActivationMiceMice, Inbred MRL lprMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProtein BindingProtein Processing, Post-TranslationalRibonucleoproteins, Small NuclearT-LymphocytesConceptsSystemic lupus erythematosusAutoimmune responseT cell autoimmune responsesHuman systemic lupus erythematosusInitiation of autoimmunityT cell compartmentT cell responsesImmunization of miceFunctioning immune systemLupus erythematosusSelf antigensAutoimmune diseasesImmunologic stimuliC-peptidePeptide autoantigensImmune systemCell responsesForeign pathogensImmunizationCytochrome c peptideMiceCell compartmentPresent studyPeptidesResponse
1992
Anti-Ro autoantibody with cross-reactive binding to the heavy chain of immunoglobulin G.
Mamula M, Harley J. Anti-Ro autoantibody with cross-reactive binding to the heavy chain of immunoglobulin G. The Yale Journal Of Biology And Medicine 1992, 65: 277-87. PMID: 1290272, PMCID: PMC2589586.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAutoantigensBinding, CompetitiveCattleCross ReactionsCyanogen BromideEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin Fab FragmentsImmunoglobulin Fc FragmentsImmunoglobulin GImmunoglobulin Heavy ChainsLupus Erythematosus, SystemicPeptide FragmentsPrecipitin TestsRabbitsRibonucleoproteinsRNA, Small CytoplasmicConceptsSystemic lupus erythematosusRo antibodiesAutoimmune diseasesCross-reactive bindingSera of patientsAnti-Ro autoantibodiesHeavy chainAnti-Ro seraFragments of IgGRo proteinLupus erythematosusCyanogen bromide digestion fragmentsAntigenic stimulusRo seraPatient seraAutoantibodiesIgGFine specificityImmunologic determinantsRo responseImmunoglobulin GSerumAntibodiesRo particleRabbit serum
1991
Importance of the immune response to the Ro/La particle in the development of congenital heart block and neonatal lupus erythematosus.
Silverman E, Mamula M, Hardin J, Laxer R. Importance of the immune response to the Ro/La particle in the development of congenital heart block and neonatal lupus erythematosus. The Journal Of Rheumatology 1991, 18: 120-4. PMID: 2023181.Peer-Reviewed Original ResearchConceptsNeonatal lupus erythematosusCongenital heart blockAnti-La antibodiesHeart blockImmune responseLupus erythematosusCutaneous neonatal lupus erythematosusAnti-U1RNP antibodiesAnti-Ro antibodiesRo antibodiesAnti-RoLa antibodiesAntibodiesErythematosusAssay techniquesPrevious studiesResponsePatientsInfantsPathogenesisWomen
1989
The Ro ribonucleoprotein particle: Induction of autoantibodies and the detection of Ro RNAs among species
Mamula M, O'Brien C, Harley J, Hardin J. The Ro ribonucleoprotein particle: Induction of autoantibodies and the detection of Ro RNAs among species. Clinical Immunology 1989, 52: 435-446. PMID: 2503280, DOI: 10.1016/0090-1229(89)90158-x.Peer-Reviewed Original ResearchConceptsRo RNAsInduction of autoantibodiesSystemic lupus erythematosusRo particleAnti-Ro autoantibodiesCell linesRabbit cell linesSjogren's syndromeLupus erythematosusHuman autoimmune seraRo seraImmune responseHigh titersAutoantibodiesAutoimmune seraSerumRabbit serumSolid-phase assaysRabbit antibodiesHuman cellsImmunodiffusion studiesSyndromeBovine cell linesTissue extractsPrecipitin line