2001
Lupus autoantigens: Their origins, forms, and presentation
Doyle H, Yan J, Liang B, Mamula M. Lupus autoantigens: Their origins, forms, and presentation. Immunologic Research 2001, 24: 131-147. PMID: 11594452, DOI: 10.1385/ir:24:2:131.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusMaintenance of autoimmunityT cell compartmentCentral lymphoid organsT cell developmentAutoimmune processLupus erythematosusAntigenic sinAutoreactive cellsAutoimmune diseasesLymphoid organsPresenting cellsB lymphocytesImmune systemAutoimmunityCell compartmentNumber of mechanismsCell developmentInductionErythematosusCellsLupusForeign proteinsLymphocytesCostimulation
2000
Molecular mimicry and the role of B lymphocytes in the processing of autoantigens
Liang B, Mamula* M. Molecular mimicry and the role of B lymphocytes in the processing of autoantigens. Cellular And Molecular Life Sciences 2000, 57: 561-568. PMID: 11130456, PMCID: PMC11147036, DOI: 10.1007/pl00000718.Peer-Reviewed Original ResearchConceptsSelf proteinsB lymphocytesAutoimmune T cell responsesT cell responsesT lymphocyte repertoireAutoreactive cellsSelf antigensAutoimmune diseasesElicit autoimmunityT lymphocytesSelf toleranceSelf peptidesImmune systemMolecular mimicryCell responsesLymphocyte repertoireLymphocytesNormal inhabitantPathogenic agentsInappropriate levelsForeign peptidesMolecular mimicsAutoimmunityAutoantigens
1998
Autoreactive B Cell Regulation: Peripheral Induction of Developmental Arrest by Lupus-Associated Autoantigens
Santulli-Marotto S, Retter M, Gee R, Mamula M, Clarke S. Autoreactive B Cell Regulation: Peripheral Induction of Developmental Arrest by Lupus-Associated Autoantigens. Immunity 1998, 8: 209-219. PMID: 9492002, DOI: 10.1016/s1074-7613(00)80473-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantigensB-LymphocytesBone MarrowCell DifferentiationDNA, Single-StrandedEnzyme-Linked Immunosorbent AssayFluorescent Antibody TechniqueGene Rearrangement, B-Lymphocyte, Heavy ChainHematopoietic Stem CellsHybridomasImmune ToleranceLupus Erythematosus, SystemicLymphocyte ActivationMiceMice, Inbred MRL lprMice, TransgenicRibonucleoproteins, Small NuclearSnRNP Core ProteinsSpleenConceptsB cellsAnti-Sm B cellsAnti-ssDNA antibodiesB-cell phenotypeImmature B-cell phenotypeImmature B cellsAutoreactive cellsMurine lupusPeripheral inductionTolerance inductionVH-D-JH rearrangementsTransgenic miceAnti-Sm hybridomasSplenic repertoireCell phenotypeSpontaneous activationCellsInductionLupusImmunizationAutoantigensLater stagesDevelopmental arrestMiceSecretion