1998
Epitope spreading: the role of self peptides and autoantigen processing by B lymphocytes
Mamula M, Mamula M. Epitope spreading: the role of self peptides and autoantigen processing by B lymphocytes. Immunological Reviews 1998, 164: 231-233. PMID: 9795779, DOI: 10.1111/j.1600-065x.1998.tb01223.x.Peer-Reviewed Original ResearchConceptsImmune responseB lymphocytesAutoantigen-presenting cellsProductive immune responseDiverse immune responsesAutoantigen processingAutoimmune diseasesSelf antigensImmune attackSelf constituentsAntigen leadSelf peptidesViral infectionInfectious agentsImmune systemSelf tissuesAntigenPotential roleAutoimmunityLymphocytesEpitopesConcept of epitopeCellsAgentsInfection
1997
B Lymphocytes as Autoantigen‐presenting Cells in the Amplification of Autoimmunitya
ROTH R, GEE R, MAMULA M. B Lymphocytes as Autoantigen‐presenting Cells in the Amplification of Autoimmunitya. Annals Of The New York Academy Of Sciences 1997, 815: 88-100. PMID: 9186642, DOI: 10.1111/j.1749-6632.1997.tb52047.x.Peer-Reviewed Original ResearchConceptsB cell-deficient miceCell-deficient miceNaive T cellsT cellsSelf antigensIL-4IL-5B cellsB7-2 costimulatory moleculesAutoantigen-presenting cellsAutoreactive T cellsT cell toleranceAntigen-presenting cellsCytokine mRNA responsesB cell subsetsNaive lymphAutoimmune responseCell subsetsCostimulatory moleculesAntigen presentationCytokine mRNAIFN-gammaB lymphocytesCell toleranceMRNA response