2007
Activation and Inhibition of the EGF Receptor
Lemmon M. Activation and Inhibition of the EGF Receptor. The FASEB Journal 2007, 21: a46-a46. DOI: 10.1096/fasebj.21.5.a46-b.Peer-Reviewed Original ResearchReceptor tyrosine kinasesEGFR extracellular regionEGF-induced dimerizationActivation of EGFRErbB family receptor tyrosine kinasesKekkon-1D. melanogasterEpidermal growth factor receptorC. elegansLigand sinkMembrane proteinsGrowth factor receptorExtracellular regionEGF receptorExtracellular domainTyrosine kinaseCurrent mechanistic viewsCell surfaceHuman cancersCell growthOrthologsFactor receptorMechanistic viewNovel EGFRDimerization
2003
Molecular Determinants of tGolgin-1 Function
Yoshino A, Marks M, Lemmon M. Molecular Determinants of tGolgin-1 Function. 2003 DOI: 10.21236/ada418143.Peer-Reviewed Original ResearchTrans-Golgi networkGRIP domainMammalian cellsC-terminal GRIP domainDynein/dynactin complexGRIP domain proteinsPeripheral membrane proteinsGTPase cascadeDomain proteinsDynactin complexGolgi networkMembrane proteinsCell motilityTurn bindsGolgi complexProtein resultsMolecular determinantsProteinTumor developmentOrthologuesCellsDomainRNAiEndosomesYeast
2002
Molecular Determinants of tGolgin-1 Function
Yoshino A, Marks M, Lemmon M. Molecular Determinants of tGolgin-1 Function. 2002 DOI: 10.21236/ada408101.Peer-Reviewed Original ResearchTrans-Golgi networkGRIP domainC-terminal GRIP domainGRIP domain proteinsPeripheral membrane proteinsN-terminal domainDomain proteinsGolgi networkTGN structureMammalian cellsGolgin-97Membrane proteinsCell motilityMolecular basisGolgi complexMolecular determinantsBroader roleCoil regionProteinTumor metastasisProtein contentCellsDomainRNAiMicrotubules
1996
Ala‐insertion scanning mutagenesis of the glycophorin a transmembrane helix: A rapid way to map helix‐helix interactions in integral membrane proteins
Mingarro I, Whitley P, Von Heijne G, Lemmon M. Ala‐insertion scanning mutagenesis of the glycophorin a transmembrane helix: A rapid way to map helix‐helix interactions in integral membrane proteins. Protein Science 1996, 5: 1339-1341. PMID: 8819166, PMCID: PMC2143459, DOI: 10.1002/pro.5560050712.Peer-Reviewed Original Research
1995
Helix-helix interactions inside membranes
Engelman D, Adair B, Brunger A, Hunt J, Kahn T, Lemmon M, MacKenzie K, Treutlein H. Helix-helix interactions inside membranes. Molecular And Cell Biology Updates 1995, 297-310. DOI: 10.1007/978-3-0348-9057-1_21.Peer-Reviewed Original Research
1994
Specificity and promiscuity in membrane helix interactions
Lemmon M, Engelman D. Specificity and promiscuity in membrane helix interactions. FEBS Letters 1994, 346: 17-20. PMID: 8206151, DOI: 10.1016/0014-5793(94)00467-6.Peer-Reviewed Original ResearchSpecificity and promiscuity in membrane helix interactions
Lemmon M, Engelman D. Specificity and promiscuity in membrane helix interactions. Quarterly Reviews Of Biophysics 1994, 27: 157-218. PMID: 7984776, DOI: 10.1017/s0033583500004522.Peer-Reviewed Original ResearchConceptsIntegral membrane proteinsTransmembrane α-helicesMembrane proteinsΑ-helixMembrane protein foldingMembrane-spanning portionTransmembrane helix associationHelix-helix interactionsParticular helicesProtein foldingHelix associationHelix interactionsProsthetic groupLipid bilayersCharge-charge interactionsStereochemical fitFoldingProteinAccessible statesSpecificityOligomerizationInteractionPromiscuityHelixAssemblyA dimerization motif for transmembrane α–helices
Lemmon M, Treutlein H, Adams P, Brünger A, Engelman D. A dimerization motif for transmembrane α–helices. Nature Structural & Molecular Biology 1994, 1: 157-163. PMID: 7656033, DOI: 10.1038/nsb0394-157.Peer-Reviewed Original ResearchConceptsTransmembrane α-helicesHydrophobic transmembrane α-helicesSpecific helix-helix interactionsΑ-helixIntegral membrane proteinsHelix-helix interactionsHelix-helix interfaceDimerization motifSpecific dimerizationMembrane proteinsHelix associationFunctional analysisAmino acidsSuch motifsLipid bilayersMotifParticular motifsFoldingDimerizationSuch interactionsComplex membranesProteinOligomerizationVariety of systemsInteraction
1993
Simulation of helix association in membranes: modeling the glycophorin A transmembrane domain
Treutlein H, Lemmon M, Engleman D, Brunger A. Simulation of helix association in membranes: modeling the glycophorin A transmembrane domain. 1993, i: 708-714 vol.1. DOI: 10.1109/hicss.1993.270670.Peer-Reviewed Original ResearchDimeric membrane proteinAmino acid sequenceRight-handed supercoilTransmembrane domainTransmembrane structureMembrane proteinsTransmembrane regionHelical proteinsMutagenesis dataHelix associationSecondary structureGlycophorin ALipid bilayersHelical dimerProteinStructural informationHelixConformationLocal energy minimaMembraneMolecular dynamics simulationsSupercoilsMutagenesisEnergy minimaInteraction energy
1992
Helix-helix interactions inside lipid bilayers
Lemmon M, Engelman D. Helix-helix interactions inside lipid bilayers. Current Opinion In Structural Biology 1992, 2: 511-518. PMCID: PMC7133266, DOI: 10.1016/0959-440x(92)90080-q.Peer-Reviewed Original ResearchTransmembrane α-helicesHelix-helix interactionsΑ-helixSingle transmembrane α-helixMechanism of transmembraneIntegral membrane proteinsNumber of proteinsMembrane-bound receptorsTransmembrane helicesInterhelical salt bridgesMembrane proteinsSoluble proteinSuch oligomerizationEndoplasmic reticulumHydrophobic anchorSuch helicesProteinLipid bilayersSalt bridgePacking interactionsOligomerizationSpecific interactionsCrystallographic studiesHelixGolgi