1994
Specificity and promiscuity in membrane helix interactions
Lemmon M, Engelman D. Specificity and promiscuity in membrane helix interactions. Quarterly Reviews Of Biophysics 1994, 27: 157-218. PMID: 7984776, DOI: 10.1017/s0033583500004522.Peer-Reviewed Original ResearchConceptsIntegral membrane proteinsTransmembrane α-helicesMembrane proteinsΑ-helixMembrane protein foldingMembrane-spanning portionTransmembrane helix associationHelix-helix interactionsParticular helicesProtein foldingHelix associationHelix interactionsProsthetic groupLipid bilayersCharge-charge interactionsStereochemical fitFoldingProteinAccessible statesSpecificityOligomerizationInteractionPromiscuityHelixAssemblyA dimerization motif for transmembrane α–helices
Lemmon M, Treutlein H, Adams P, Brünger A, Engelman D. A dimerization motif for transmembrane α–helices. Nature Structural & Molecular Biology 1994, 1: 157-163. PMID: 7656033, DOI: 10.1038/nsb0394-157.Peer-Reviewed Original ResearchConceptsTransmembrane α-helicesHydrophobic transmembrane α-helicesSpecific helix-helix interactionsΑ-helixIntegral membrane proteinsHelix-helix interactionsHelix-helix interfaceDimerization motifSpecific dimerizationMembrane proteinsHelix associationFunctional analysisAmino acidsSuch motifsLipid bilayersMotifParticular motifsFoldingDimerizationSuch interactionsComplex membranesProteinOligomerizationVariety of systemsInteraction
1993
Simulation of helix association in membranes: modeling the glycophorin A transmembrane domain
Treutlein H, Lemmon M, Engleman D, Brunger A. Simulation of helix association in membranes: modeling the glycophorin A transmembrane domain. 1993, i: 708-714 vol.1. DOI: 10.1109/hicss.1993.270670.Peer-Reviewed Original ResearchDimeric membrane proteinAmino acid sequenceRight-handed supercoilTransmembrane domainTransmembrane structureMembrane proteinsTransmembrane regionHelical proteinsMutagenesis dataHelix associationSecondary structureGlycophorin ALipid bilayersHelical dimerProteinStructural informationHelixConformationLocal energy minimaMembraneMolecular dynamics simulationsSupercoilsMutagenesisEnergy minimaInteraction energy