2024
REliable PIcking by Consensus (REPIC): a consensus methodology for harnessing multiple cryo-EM particle pickers
Cameron C, Seager S, Sigworth F, Tagare H, Gerstein M. REliable PIcking by Consensus (REPIC): a consensus methodology for harnessing multiple cryo-EM particle pickers. Communications Biology 2024, 7: 1421. PMID: 39482410, PMCID: PMC11528043, DOI: 10.1038/s42003-024-07045-0.Peer-Reviewed Original ResearchConceptsCryo-EM usersParticle identificationParticle pickingLow signal-to-noise ratioAchievable resolutionSignal-to-noise ratioState-of-the-art computational algorithmsInteger linear programmingParticle setManual interventionHigh-quality particlesGraph problemsParticle locationMultiple pickersParticles
2009
PeakSeq enables systematic scoring of ChIP-seq experiments relative to controls
Rozowsky J, Euskirchen G, Auerbach RK, Zhang ZD, Gibson T, Bjornson R, Carriero N, Snyder M, Gerstein MB. PeakSeq enables systematic scoring of ChIP-seq experiments relative to controls. Nature Biotechnology 2009, 27: 66-75. PMID: 19122651, PMCID: PMC2924752, DOI: 10.1038/nbt.1518.Peer-Reviewed Original Research
2004
Genomic analysis of regulatory network dynamics reveals large topological changes
Luscombe NM, Madan Babu M, Yu H, Snyder M, Teichmann SA, Gerstein M. Genomic analysis of regulatory network dynamics reveals large topological changes. Nature 2004, 431: 308-312. PMID: 15372033, DOI: 10.1038/nature02782.Peer-Reviewed Original ResearchConceptsTranscription factorsActive transcription factorRegulatory network dynamicsBiological networksHigher eukaryotesLarge-scale topological changesGenomic scaleGenomic analysisCell cycleDiverse stimuliEnvironmental responsesMolecular biologyFast signal propagationTwo-tiered hierarchyNetwork analysisGlobal topological measuresLocal motifsSub-network structureEukaryotesTemporal progression
2003
MolMovDB: analysis and visualization of conformational change and structural flexibility
Echols N, Milburn D, Gerstein M. MolMovDB: analysis and visualization of conformational change and structural flexibility. Nucleic Acids Research 2003, 31: 478-482. PMID: 12520056, PMCID: PMC165551, DOI: 10.1093/nar/gkg104.Peer-Reviewed Original Research