2021
microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity
Horie T, Nakao T, Miyasaka Y, Nishino T, Matsumura S, Nakazeki F, Ide Y, Kimura M, Tsuji S, Rodriguez RR, Watanabe T, Yamasaki T, Xu S, Otani C, Miyagawa S, Matsushita K, Sowa N, Omori A, Tanaka J, Nishimura C, Nishiga M, Kuwabara Y, Baba O, Watanabe S, Nishi H, Nakashima Y, Picciotto MR, Inoue H, Watanabe D, Nakamura K, Sasaki T, Kimura T, Ono K. microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity. Nature Communications 2021, 12: 843. PMID: 33594062, PMCID: PMC7886914, DOI: 10.1038/s41467-021-21107-5.Peer-Reviewed Original ResearchConceptsSympathetic nerve activityAdaptive thermogenesisNerve activityCre miceMiR-33Brown adipose tissue thermogenesisDBH-positive neuronsMiR-33 levelsGABAergic inhibitory neurotransmissionSympathetic nerve toneCentral neural circuitsAdipose tissue thermogenesisGamma-aminobutyric acidDBH-positive cellsMiR-33 deficiencyWhole-body metabolismCold-induced thermogenesisInhibitory neurotransmissionBAT thermogenesisTissue thermogenesisReceptor subunit genesNeural circuitsAdaptive defense mechanismsThermogenesisMice
2010
MicroRNA knocks down cocaine
Picciotto MR. MicroRNA knocks down cocaine. Nature 2010, 466: 194-195. PMID: 20613832, DOI: 10.1038/466194a.Peer-Reviewed Original Research