2004
Patterns of Inflammation in Mucosal Biopsies of Ulcerative Colitis
Robert M, Tang L, Hao L, Reyes-Mugica M. Patterns of Inflammation in Mucosal Biopsies of Ulcerative Colitis. The American Journal Of Surgical Pathology 2004, 28: 183-189. PMID: 15043307, DOI: 10.1097/00000478-200402000-00005.Peer-Reviewed Original ResearchConceptsColonic mucosal biopsiesCrypt architectural distortionYears of ageEpithelial injuryMucosal biopsiesUlcerative colitisHistological featuresArchitectural distortionRectal biopsyCrypt abscessesPresentation of ulcerative colitisYears of follow-upInitiation of therapyPlasma cell infiltrationDiagnosis of ulcerative colitisPattern of inflammationDegree of colitisDegree of inflammationAge groupsDiagnosed ulcerative colitisPathological confirmationInitial presentationCrypt branchingNo significant differenceHistological criteria
1997
Characterization of afferent mechanisms in ileoanal pouches.
Bernstein C, Rollandelli R, Niazi N, Robert M, Hirsh T, Munakata J, Mayer E. Characterization of afferent mechanisms in ileoanal pouches. The American Journal Of Gastroenterology 1997, 92: 103-8. PMID: 8995947.Peer-Reviewed Original ResearchConceptsIleoanal pouchPouch complianceProximal ileumActive ulcerative colitisAnal sphincter functionAfferent nerve functionBalloon distentionIntrapouch pressureS3 dermatomesNerve functionPouch functionSphincter functionAfferent mechanismsUlcerative colitisAfferent innervationClinical featuresClinical presentationColorectal inflammationReferral patternsReflex functionReflex regulationAfferent pathwaysDistention pressuresLower volume thresholdRamp distention
1996
Rectal afferent function in patients with inflammatory and functional intestinal disorders
Bernstein C, Niazi N, Robert M, Mertz H, Kodner A, Munakata J, Naliboff B, Mayer E. Rectal afferent function in patients with inflammatory and functional intestinal disorders. Pain 1996, 66: 151-161. PMID: 8880836, DOI: 10.1016/0304-3959(96)03062-x.Peer-Reviewed Original ResearchConceptsIrritable bowel syndromeInflammatory bowel diseaseDiarrhea-predominant irritable bowel syndromeViscerosomatic referral patternCrohn's disease patientsIBS patientsDisease patientsCrohn's diseaseMale patientsReferral patternsAfferent pathwaysReflex responsesHealthy male control subjectsTissue irritationAutonomic reflex responsesChronic ileal inflammationLower distension pressuresRapid phasic distensionDorsal horn neuronsVisceral afferent pathwaysIleal Crohn's diseaseFunctional intestinal disordersMale control subjectsSkin conductance responsesBulbospinal inhibition
1993
Rectal substance P concentrations are increased in ulcerative colitis but not in Crohn's disease.
Bernstein C, Robert M, Eysselein V. Rectal substance P concentrations are increased in ulcerative colitis but not in Crohn's disease. The American Journal Of Gastroenterology 1993, 88: 908-13. PMID: 7684884.Peer-Reviewed Original ResearchConceptsSubstance P concentrationsSubstance P levelsCrohn's diseaseUlcerative colitisSubstance PIncreasing concentrations of substance PConcentrations of substance PPathogenesis of ulcerative colitisRectal mucosal biopsiesNon-inflammatory bowel disease patientsMucosal neutrophilsUC patientsMucosal levelMucosal biopsiesCD patientsAffected patientsIncreased inflammationInflammatory cellsRectal diseaseColonic mucosaInflammatory processPatientsDisease patientsBiopsyMotor phenomena