2020
Elective Colectomy in a Patient with Active Ulcerative Colitis and Metastatic Melanoma Enabling Successful Treatment with Immune Checkpoint Inhibitors.
Perdigoto AL, Tran T, Patel N, Clark P, Patell K, Stamatouli AM, Reddy V, Clune J, Herold KC, Robert ME, Kluger HM. Elective Colectomy in a Patient with Active Ulcerative Colitis and Metastatic Melanoma Enabling Successful Treatment with Immune Checkpoint Inhibitors. Clinical Oncology Case Reports 2020, 3 PMID: 33778814, PMCID: PMC7993656.Peer-Reviewed Original ResearchCheckpoint inhibitor therapyElective colectomyUlcerative colitisInhibitor therapyMetastatic melanomaImmune-related adverse eventsExcellent tumor responseImmune checkpoint inhibitorsSevere ulcerative colitisActive ulcerative colitisCheckpoint inhibitor immunotherapyCheckpoint inhibitor treatmentInflammatory bowel diseaseEffective treatment optionBenefits of treatmentImmune system activationTumor cell destructionCheckpoint inhibitorsAdvanced malignanciesAdverse eventsSelect patientsBowel diseaseAutoimmune diseasesTreatment optionsTumor response
1996
Diffuse colonic mantle cell lymphoma in a patient with presumed ulcerative colitis: detection of a precursor monoclonal lymphoid population using polymerase chain reaction and immunohistochemistry.
Robert M, Kuo F, Longtine J, Sklar J, Schrock T, Weidner N. Diffuse colonic mantle cell lymphoma in a patient with presumed ulcerative colitis: detection of a precursor monoclonal lymphoid population using polymerase chain reaction and immunohistochemistry. The American Journal Of Surgical Pathology 1996, 20: 1024-31. PMID: 8712289, DOI: 10.1097/00000478-199608000-00011.Peer-Reviewed Original ResearchConceptsUlcerative colitisColonic lymphomaMantle cell lymphomaMucosal changesCell lymphomaInflammatory mucosal changesPrimary colonic lymphomaSevere ulcerative colitisImmunoglobulin heavy chain gene rearrangementHigh-grade morphologyHeavy chain gene rearrangementMonoclonal lymphoid populationLate complicationsMucosal injuryUnderlying diseasePrimary lymphomaFurther workupInitial diagnosisResection specimenPolymerase chain reactionSuperficial biopsiesLymphoid proliferationsColitisLymphoid populationsLymphoma