False negative PCR despite high levels of JC virus DNA in spinal fluid: Implications for diagnostic testing
Landry ML, Eid T, Bannykh S, Major E. False negative PCR despite high levels of JC virus DNA in spinal fluid: Implications for diagnostic testing. Journal Of Clinical Virology 2008, 43: 247-249. PMID: 18701345, PMCID: PMC2683978, DOI: 10.1016/j.jcv.2008.07.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultDNA, ViralFalse Negative ReactionsFemaleHumansJC VirusJob SyndromeLeukoencephalopathy, Progressive MultifocalPolymerase Chain ReactionConceptsProgressive multifocal leukoencephalopathyPolymerase chain reactionHerpes simplex virus polymerase chain reactionSpinal fluidCSF polymerase chain reactionNegative polymerase chain reactionFatal neurologic illnessesJC virus DNAFalse-negative polymerase chain reactionHigher positive resultsMultifocal leukoencephalopathyBrain biopsyNeurologic illnessDNA polymerase chain reactionNeurologic diseaseBlinded studyPCR testingDiagnostic testingVirus DNAReference laboratoryYoung mothersChain reactionNegative resultsDifferent virusesPositive results