2024
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children
Watkins T, Green A, Amat J, Cheemarla N, Hänsel K, Lozano R, Dudgeon S, Germain G, Landry M, Schulz W, Foxman E. High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children. Journal Of Experimental Medicine 2024, 221: e20230911. PMID: 38949638, PMCID: PMC11215523, DOI: 10.1084/jem.20230911.Peer-Reviewed Original ResearchConceptsBacterial pathobiontsRespiratory virusesBurden of virusesSARS-CoV-2Innate immune activationSARS-CoV-2 viral loadDynamic host-pathogen interactionsInnate immune responseViral coinfectionCytokine profileViral loadNasal virusImmune activationProinflammatory responseIL-1BNasopharyngeal samplesHost-pathogen interactionsImmune responseInterferon responsePathobiontsInnate immunityPaired samplesCXCL10Healthy 1-year-oldVirus
2023
Lymphocytic Choriomeningitis Virus in Person Living with HIV, Connecticut, USA, 2021 - Volume 29, Number 9—September 2023 - Emerging Infectious Diseases journal - CDC
Dyal J, Gandhi S, Cossaboom C, Leach A, Patel K, Golden M, Canterino J, Landry M, Cannon D, Choi M, Krapiunaya I, Klena J, Shoemaker T. Lymphocytic Choriomeningitis Virus in Person Living with HIV, Connecticut, USA, 2021 - Volume 29, Number 9—September 2023 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2023, 29: 1886-1889. PMID: 37610188, PMCID: PMC10461659, DOI: 10.3201/eid2909.230087.Peer-Reviewed Original Research
2016
Sensitive Detection and Simultaneous Discrimination of Influenza A and B Viruses in Nasopharyngeal Swabs in a Single Assay Using Next-Generation Sequencing-Based Diagnostics
Zhao J, Liu J, Vemula SV, Lin C, Tan J, Ragupathy V, Wang X, Mbondji-wonje C, Ye Z, Landry ML, Hewlett I. Sensitive Detection and Simultaneous Discrimination of Influenza A and B Viruses in Nasopharyngeal Swabs in a Single Assay Using Next-Generation Sequencing-Based Diagnostics. PLOS ONE 2016, 11: e0163175. PMID: 27658193, PMCID: PMC5033603, DOI: 10.1371/journal.pone.0163175.Peer-Reviewed Original ResearchB virusInfluenza AInfluenza types/subtypesInfluenza virusPandemic influenza virusInfluenza B virusTypes/subtypesInfluenza viral genomeE627K mutationAntiviral treatmentNasopharyngeal swabsInfluenza strainsLaboratory confirmationPandemic potentialS31N mutationPatient specimensClinical settingNGS assaysDrug resistance markersVirusFurther studiesCurrent diagnostic platformsPublic healthK mutationInfluenza
2015
Nanomicroarray and Multiplex Next-Generation Sequencing for Simultaneous Identification and Characterization of Influenza Viruses - Volume 21, Number 3—March 2015 - Emerging Infectious Diseases journal - CDC
Zhao J, Ragupathy V, Liu J, Wang X, Vemula SV, Mubarak H, Ye Z, Landry ML, Hewlett I. Nanomicroarray and Multiplex Next-Generation Sequencing for Simultaneous Identification and Characterization of Influenza Viruses - Volume 21, Number 3—March 2015 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2015, 21: 400-408. PMID: 25694248, PMCID: PMC4344273, DOI: 10.3201/eid2103.141169.Peer-Reviewed Original ResearchConceptsMultiplex next-generation sequencingNext-generation sequencingInfluenza virusInfectious Diseases journal - CDCPotential influenza pandemicFuture epidemiologic studiesPublic health benefitsNew diagnostic algorithmInfluenza infectionB virusInfluenza AInfluenza pandemicEpidemiologic studiesMultiple influenzaLaboratory confirmationDiagnostic algorithmHealth benefitsNGS assaysVirusInfluenzaSubtypesMatrix genesGene segmentsDiagnostic platformConfirmationToscana Virus Encephalitis in a Traveler Returning to the United States
Howell BA, Azar MM, Landry ML, Shaw AC. Toscana Virus Encephalitis in a Traveler Returning to the United States. Journal Of Clinical Microbiology 2015, 53: 1445-1447. PMID: 25673791, PMCID: PMC4365192, DOI: 10.1128/jcm.03498-14.Peer-Reviewed Case Reports and Technical Notes
2014
A Highly Sensitive Europium Nanoparticle-Based Immunoassay for Detection of Influenza A/B Virus Antigen in Clinical Specimens
Zhang P, Vemula SV, Zhao J, Du B, Mohan H, Liu J, Mubarak H, Landry ML, Hewlett I. A Highly Sensitive Europium Nanoparticle-Based Immunoassay for Detection of Influenza A/B Virus Antigen in Clinical Specimens. Journal Of Clinical Microbiology 2014, 52: 4385-4387. PMID: 25297327, PMCID: PMC4313323, DOI: 10.1128/jcm.02635-14.Peer-Reviewed Original Research
2009
WU Polyomavirus in Patients Infected with HIV or Hepatitis C Virus, Connecticut, USA, 2007 - Volume 15, Number 7—July 2009 - Emerging Infectious Diseases journal - CDC
Miller MA, Weibel C, Ferguson D, Landry ML, Kahn JS. WU Polyomavirus in Patients Infected with HIV or Hepatitis C Virus, Connecticut, USA, 2007 - Volume 15, Number 7—July 2009 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2009, 15: 1095-1097. PMID: 19624928, PMCID: PMC2744261, DOI: 10.3201/eid1507.090150.Peer-Reviewed Original Research
2008
Role of Human Polyomaviruses in Respiratory Tract Disease in Young Children - Volume 14, Number 11—November 2008 - Emerging Infectious Diseases journal - CDC
Wattier RL, Vázquez M, Weibel C, Shapiro ED, Ferguson D, Landry ML, Kahn JS. Role of Human Polyomaviruses in Respiratory Tract Disease in Young Children - Volume 14, Number 11—November 2008 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2008, 14: 1766-1768. PMID: 18976566, PMCID: PMC2630739, DOI: 10.3201/eid1411.080394.Peer-Reviewed Original Research
2006
Coronavirus HKU1 Infection in the United States
Esper F, Weibel C, Ferguson D, Landry ML, Kahn JS. Coronavirus HKU1 Infection in the United States. Emerging Infectious Diseases 2006, 12: 775-779. PMID: 16704837, PMCID: PMC3374449, DOI: 10.3201/eid1205.051316.Peer-Reviewed Original ResearchConceptsHCoV-HKU1Respiratory specimensLower respiratory tract infectionsLower respiratory tract diseaseHCoV-HKU1 infectionRespiratory tract infectionsRespiratory syncytial virusRespiratory tract diseaseReverse transcription-polymerase chain reactionNew human coronavirusYears of ageTranscription-polymerase chain reactionTract infectionsSyncytial virusPositive childrenParainfluenza virusTract diseaseRespiratory tractHuman coronavirusesPositive specimensInfluenza virusInfectionChain reactionChildrenVirus
2003
Suboptimal Detection of Influenza Virus in Adults by the Directigen Flu A+B Enzyme Immunoassay and Correlation of Results with the Number of Antigen-Positive Cells Detected by Cytospin Immunofluorescence
Landry ML, Ferguson D. Suboptimal Detection of Influenza Virus in Adults by the Directigen Flu A+B Enzyme Immunoassay and Correlation of Results with the Number of Antigen-Positive Cells Detected by Cytospin Immunofluorescence. Journal Of Clinical Microbiology 2003, 41: 3407-3409. PMID: 12843105, PMCID: PMC165325, DOI: 10.1128/jcm.41.7.3407-3409.2003.Peer-Reviewed Original ResearchConceptsVirus infectionEnzyme immunoassayDirectigen FluParainfluenza virus infectionPositive EIA resultsRespiratory syncytial virusAntigen-positive cellsNasopharyngeal swabsSyncytial virusEmergency departmentInfluenza diagnosisDirect immunofluorescenceInfluenza virusVirology laboratoryEIA resultsNight shiftsInfectionInfluenzaImmunofluorescenceFluAdultsVirusCorrelation of resultsImmunoassayCells
2000
SimulFluor Respiratory Screen for Rapid Detection of Multiple Respiratory Viruses in Clinical Specimens by Immunofluorescence Staining
Landry M, Ferguson D. SimulFluor Respiratory Screen for Rapid Detection of Multiple Respiratory Viruses in Clinical Specimens by Immunofluorescence Staining. Journal Of Clinical Microbiology 2000, 38: 708-711. PMID: 10655371, PMCID: PMC86182, DOI: 10.1128/jcm.38.2.708-711.2000.Peer-Reviewed Original ResearchConceptsCommon respiratory virusesRespiratory virusesMultiple respiratory virusesVirus isolatesRespiratory samplesPatient managementDirect immunofluorescenceInfection controlClinical specimensCytospin preparationsVirusScreening reagentImmunofluorescenceCell culturesSample collectionGreat benefitIsolates
1997
Detection of herpes simplex virus in clinical specimens by cytospin-enhanced direct immunofluorescence
Landry ML, Ferguson D, Wlochowski J. Detection of herpes simplex virus in clinical specimens by cytospin-enhanced direct immunofluorescence. Journal Of Clinical Microbiology 1997, 35: 302-304. PMID: 8968933, PMCID: PMC229564, DOI: 10.1128/jcm.35.1.302-304.1997.Peer-Reviewed Original Research
1992
An adventitious viral contaminant in commercially supplied A549 cells: identification of infectious bovine rhinotracheitis virus and its impact on diagnosis of infection in clinical specimens
Fong CK, Landry ML. An adventitious viral contaminant in commercially supplied A549 cells: identification of infectious bovine rhinotracheitis virus and its impact on diagnosis of infection in clinical specimens. Journal Of Clinical Microbiology 1992, 30: 1611-1613. PMID: 1320632, PMCID: PMC265345, DOI: 10.1128/jcm.30.6.1611-1613.1992.Peer-Reviewed Original ResearchHerpes Simplex Types 1 and 2: Latency in the Genital Tract of Guinea Pigs
Landry M, Bull C. Herpes Simplex Types 1 and 2: Latency in the Genital Tract of Guinea Pigs. Intervirology 1992, 33: 204-210. PMID: 1326498, DOI: 10.1159/000150252.Peer-Reviewed Original Research
1987
Replication of human adenoviruses in guinea pig embryo cells: an ultrastructural study
Fong C, Landry M, Hsiung GD. Replication of human adenoviruses in guinea pig embryo cells: an ultrastructural study. Archives Of Virology 1987, 93: 247-260. PMID: 3827599, DOI: 10.1007/bf01310978.Peer-Reviewed Original ResearchConceptsProgeny virusAdenovirus 2Cellular changesEmbryo cellsHuman adenovirus 2Adenovirus typesHuman cellsCell typesAdenovirus 3Human adenovirusesCellsProtein crystalsElectron microscopic examinationAdenovirus 31Human adenovirus typesAdenovirus 7Virus infectivity assaysInfectivity assaysBiological propertiesUltrastructural studyVirusGuinea pig embryo cellsInfectious virusReplicationCharacteristic fibers
1983
Herpes simplex encephalitis: analysis of a cluster of cases by restriction endonuclease mapping of virus isolates.
Landry M, Berkovits N, Summers W, Booss J, Hsiung G, Summers W. Herpes simplex encephalitis: analysis of a cluster of cases by restriction endonuclease mapping of virus isolates. Neurology 1983, 33: 831-5. PMID: 6306505, DOI: 10.1212/wnl.33.7.831.Peer-Reviewed Original Research