2023
Nasal host response-based screening for undiagnosed respiratory viruses: a pathogen surveillance and detection study
Cheemarla N, Hanron A, Fauver J, Bishai J, Watkins T, Brito A, Zhao D, Alpert T, Vogels C, Ko A, Schulz W, Landry M, Grubaugh N, van Dijk D, Foxman E. Nasal host response-based screening for undiagnosed respiratory viruses: a pathogen surveillance and detection study. The Lancet Microbe 2023, 4: e38-e46. PMID: 36586415, PMCID: PMC9835789, DOI: 10.1016/s2666-5247(22)00296-8.Peer-Reviewed Original ResearchConceptsRespiratory virus panelPg/mLCXCL10 concentrationsSARS-CoV-2Bacterial pathobiontsRespiratory virusesSARS-CoV-2 negative samplesViral respiratory infectionsSARS-CoV-2 positive samplesClinical virology laboratoryHealth care systemVirus-positive samplesQuantitative RT-PCRInfluenza C virusSymptomatic patientsRespiratory infectionsSeasonal coronavirusesNasopharyngeal swabsVirus panelC virusCommon virusesCXCL10Host responseInterferon responseVirology laboratory
2018
Adenovirus Type 4 Respiratory Infections among Civilian Adults, Northeastern United States, 2011–2015 - Volume 24, Number 2—February 2018 - Emerging Infectious Diseases journal - CDC
Kajon AE, Lamson DM, Bair CR, Lu X, Landry ML, Menegus M, Erdman DD, St. George K. Adenovirus Type 4 Respiratory Infections among Civilian Adults, Northeastern United States, 2011–2015 - Volume 24, Number 2—February 2018 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2018, 24: 201-209. PMID: 29350143, PMCID: PMC5782899, DOI: 10.3201/eid2402.171407.Peer-Reviewed Original ResearchConceptsAcute respiratory diseaseCivilian adultsInfectious Diseases journal - CDCUS military recruitsLong-term care facilitiesInfluenza-like illnessAdenovirus type 4Respiratory infectionsHuman adenovirus type 4Vaccination protocolsCancer patientsHAdV-4Respiratory diseasePhysician's officeCare facilitiesNursing homesMilitary recruitsVaccine strainYoung adultsType 4Causative agentAdultsLike variantsMilitary settingsDetailed molecular characterization
2017
Antiviral Response in the Nasopharynx Identifies Patients With Respiratory Virus Infection
Landry ML, Foxman EF. Antiviral Response in the Nasopharynx Identifies Patients With Respiratory Virus Infection. The Journal Of Infectious Diseases 2017, 217: 897-905. PMID: 29281100, PMCID: PMC5853594, DOI: 10.1093/infdis/jix648.Peer-Reviewed Original ResearchConceptsRespiratory virusesNasopharyngeal swabsViral infectionCXCL10 protein levelsPatient nasopharyngeal swabsRespiratory virus infectionsHuman nasal epithelial cellsManagement of patientsRespiratory virus detectionNasal epithelial cellsSingle host proteinVirus detectionSimple diagnostic testIdentifies patientsRespiratory symptomsRespiratory infectionsRespiratory illnessHigh burdenVirus infectionReceptor RIGCost-effective testAntiviral responseAccurate diagnosisDiagnostic testsInfection
2009
Rhinoviruses Are a Major Cause of Wheezing and Hospitalization in Children Less Than 2 Years of Age
Piotrowska Z, Vázquez M, Shapiro ED, Weibel C, Ferguson D, Landry ML, Kahn JS. Rhinoviruses Are a Major Cause of Wheezing and Hospitalization in Children Less Than 2 Years of Age. The Pediatric Infectious Disease Journal 2009, 28: 25-29. PMID: 19057454, PMCID: PMC4639321, DOI: 10.1097/inf.0b013e3181861da0.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusHRV-positive childrenHuman rhinovirusSyncytial virusAge groupsDiagnostic laboratoriesRespiratory tract diseaseMajor respiratory pathogenRate of infectionYears of ageSimilar age groupAsymptomatic childrenRespiratory specimenAsymptomatic groupRespiratory infectionsHRV infectionHospitalization ratesPolymerase chain reactionTract diseaseRespiratory pathogensHRV isolatesMajor causeStudy periodSymptomsInfection
1996
Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness.
Einarsson O, Geba G, Zhu Z, Landry M, Elias J. Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness. Journal Of Clinical Investigation 1996, 97: 915-924. PMID: 8613544, PMCID: PMC507136, DOI: 10.1172/jci118514.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusIL-11 productionParainfluenza virus type 3Airway hyperresponsivenessIL-11Viral upper respiratory tract infectionUpper respiratory tract infectionBALB/c miceSimplex virus type 2Viral-induced asthmaViral respiratory infectionsRespiratory tract infectionsNonspecific airway hyperresponsivenessVirus type 2Virus type 3Clinical bronchospasmAirway dysfunctionAirway physiologyTract infectionsRespiratory infectionsRespiratory virusesSyncytial virusC miceNasal aspiratesViral infection