2023
Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants
Moriyama M, Lucas C, Monteiro V, Initiative Y, Iwasaki A, Chen N, Breban M, Hahn A, Pham K, Koch T, Chaguza C, Tikhonova I, Castaldi C, Mane S, De Kumar B, Ferguson D, Kerantzas N, Peaper D, Landry M, Schulz W, Vogels C, Grubaugh N. Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2221652120. PMID: 37036977, PMCID: PMC10120007, DOI: 10.1073/pnas.2221652120.Peer-Reviewed Original ResearchConceptsMHC-I expressionBreakthrough infectionsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variantsMajor histocompatibility complex class I expressionCell-mediated immunityInfluenza virus infectionSARS-CoV-2 VOCsMHC-I upregulationClass I expressionSARS-CoV-2T cell recognitionVirus infectionMHC II expressionSpike proteinEnhanced inhibitionInfectionCell recognitionCommon mutationsReinfectionE proteinAntibodiesViral genesSubvariantsExpression
2022
Rapid emergence of SARS-CoV-2 Omicron variant is associated with an infection advantage over Delta in vaccinated persons
Chaguza C, Coppi A, Earnest R, Ferguson D, Kerantzas N, Warner F, Young HP, Breban MI, Billig K, Koch RT, Pham K, Kalinich CC, Ott IM, Fauver JR, Hahn AM, Tikhonova IR, Castaldi C, De Kumar B, Pettker CM, Warren JL, Weinberger DM, Landry ML, Peaper DR, Schulz W, Vogels CBF, Grubaugh ND. Rapid emergence of SARS-CoV-2 Omicron variant is associated with an infection advantage over Delta in vaccinated persons. Med 2022, 3: 325-334.e4. PMID: 35399324, PMCID: PMC8983481, DOI: 10.1016/j.medj.2022.03.010.Peer-Reviewed Original ResearchConceptsSpike gene target failureSARS-CoV-2 Omicron variantPositivity rateOmicron variantOmicron infectionVaccine dosesVaccine-induced immunityNumber of dosesTest positivity rateOdds of infectionSARS-CoV-2Significant reductionDominant Delta variantUnvaccinated personsVaccination statusHigher oddsDelta variantInfectionVaccine manufacturersDisease controlVirus copiesDosesPCR testOddsTarget failureComparative transmissibility of SARS-CoV-2 variants Delta and Alpha in New England, USA
Earnest R, Uddin R, Matluk N, Renzette N, Turbett SE, Siddle KJ, Loreth C, Adams G, Tomkins-Tinch CH, Petrone ME, Rothman JE, Breban MI, Koch RT, Billig K, Fauver JR, Vogels CBF, Bilguvar K, De Kumar B, Landry ML, Peaper DR, Kelly K, Omerza G, Grieser H, Meak S, Martha J, Dewey HB, Kales S, Berenzy D, Carpenter-Azevedo K, King E, Huard RC, Novitsky V, Howison M, Darpolor J, Manne A, Kantor R, Smole SC, Brown CM, Fink T, Lang AS, Gallagher GR, Pitzer VE, Sabeti PC, Gabriel S, MacInnis BL, Team N, Altajar A, DeJesus A, Brito A, Watkins A, Muyombwe A, Blumenstiel B, Neal C, Kalinich C, Liu C, Loreth C, Castaldi C, Pearson C, Bernard C, Nolet C, Ferguson D, Buzby E, Laszlo E, Reagan F, Vicente G, Rooke H, Munger H, Johnson H, Tikhonova I, Ott I, Razeq J, Meldrim J, Brown J, Wang J, Vostok J, Beauchamp J, Grimsby J, Hall J, Messer K, Larkin K, Vernest K, Madoff L, Green L, Webber L, Gagne L, Ulcena M, Ray M, Fisher M, Barter M, Lee M, DeFelice M, Cipicchio M, Smith N, Lennon N, Fitzgerald N, Kerantzas N, Hui P, Harrington R, Downing R, Haye R, Lynch R, Anderson S, Hennigan S, English S, Cofsky S, Clancy S, Mane S, Ash S, Baez S, Fleming S, Murphy S, Chaluvadi S, Alpert T, Rivard T, Schulz W, Mandese Z, Tewhey R, Adams M, Park D, Lemieux J, Grubaugh N. Comparative transmissibility of SARS-CoV-2 variants Delta and Alpha in New England, USA. Cell Reports Medicine 2022, 3: 100583. PMID: 35480627, PMCID: PMC8913280, DOI: 10.1016/j.xcrm.2022.100583.Peer-Reviewed Original ResearchConceptsEnhanced transmissibilitySARS-CoV-2 variant DeltaSARS-CoV-2 Delta variantViral RNA copiesPublic health programsAlpha infectionDelta infectionEffective reproductive numberDelta variantHealth programsVariant DeltaRNA copiesInfectionAlphaReproductive numberTransmissibilityEpidemiological dynamics
2021
Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics
Cheemarla NR, Watkins TA, Mihaylova VT, Wang B, Zhao D, Wang G, Landry ML, Foxman EF. Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics. Journal Of Experimental Medicine 2021, 218: e20210583. PMID: 34128960, PMCID: PMC8210587, DOI: 10.1084/jem.20210583.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngiotensin-Converting Enzyme 2Case-Control StudiesChemokine CXCL10COVID-19Disease SusceptibilityFemaleGene Expression ProfilingHost-Pathogen InteractionsHumansImmunity, InnateInterferonsMaleMiddle AgedNasopharynxPicornaviridae InfectionsSARS-CoV-2Viral LoadVirus ReplicationConceptsSARS-CoV-2 infectionSARS-CoV-2 exposureSARS-CoV-2Interferon-stimulated genesUpper respiratory tractRespiratory tractEarly SARS-CoV-2 infectionDynamic innate immune responseViral replicationSARS-CoV-2 replicationPatient nasopharyngeal samplesInnate immune responseLow infectious doseViral loadNasopharyngeal samplesImmune responseInfectious doseISG responseAntiviral responseInfection progressionViral transmissionLevel correlatesInfectionISG inductionInitial replication
2017
Antiviral Response in the Nasopharynx Identifies Patients With Respiratory Virus Infection
Landry ML, Foxman EF. Antiviral Response in the Nasopharynx Identifies Patients With Respiratory Virus Infection. The Journal Of Infectious Diseases 2017, 217: 897-905. PMID: 29281100, PMCID: PMC5853594, DOI: 10.1093/infdis/jix648.Peer-Reviewed Original ResearchConceptsRespiratory virusesNasopharyngeal swabsViral infectionCXCL10 protein levelsPatient nasopharyngeal swabsRespiratory virus infectionsHuman nasal epithelial cellsManagement of patientsRespiratory virus detectionNasal epithelial cellsSingle host proteinVirus detectionSimple diagnostic testIdentifies patientsRespiratory symptomsRespiratory infectionsRespiratory illnessHigh burdenVirus infectionReceptor RIGCost-effective testAntiviral responseAccurate diagnosisDiagnostic testsInfectionFatal case of cutaneous‐sparing orolaryngeal zoster in a renal transplant recipient
Helou E, Grant M, Landry M, Wu X, Morrow JS, Malinis MF. Fatal case of cutaneous‐sparing orolaryngeal zoster in a renal transplant recipient. Transplant Infectious Disease 2017, 19 PMID: 28401625, DOI: 10.1111/tid.12704.Peer-Reviewed Case Reports and Technical NotesConceptsTransplant recipientsHerpes zosterSolid organ transplant recipientsCTLA-4 inhibitorsKidney transplant recipientsRenal transplant recipientsOrgan transplant recipientsAcute rejectionSOT recipientsMucosal lesionsMeningo-encephalitisPoor outcomeFatal casesHerpesvirus infectionSignificant causeRecipientsZosterPneumonitisMorbidityPatientsLesionsInfectionMortalityCases
2016
Laboratory Diagnosis of Zika Virus Infection
Landry ML, St George K. Laboratory Diagnosis of Zika Virus Infection. Archives Of Pathology & Laboratory Medicine 2016, 141: 60-67. PMID: 27763787, DOI: 10.5858/arpa.2016-0406-sa.Peer-Reviewed Original ResearchConceptsNucleic acid amplification testsZika virus infectionZika infectionVirus infectionAmplification testsLaboratory diagnosisNucleic acid amplification testingCommercial nucleic acid amplification testsAccurate antibody testZika virus testingPublic health recommendationsEmergency use authorizationAcute infectionAmplification testingSerology resultsPast infectionFlavivirus antigensHealth recommendationsVirus testingCurrent recommendationsAntibody testApplicable diagnostic toolsVirus epitopesAccurate diagnosisInfectionImmunoglobulin M for Acute Infection: True or False?
Landry ML. Immunoglobulin M for Acute Infection: True or False? MSphere 2016, 23: 540-545. PMID: 27193039, PMCID: PMC4933779, DOI: 10.1128/cvi.00211-16.Peer-Reviewed Original ResearchConceptsClear clinical utilityFalse-positive IgMImmunoglobulin M testAcute infectionInappropriate therapyFalse-positive resultsDiagnostic workupEpidemiologic findingsIgM detectionInfection controlClinical utilityImmunoglobulin MSerial samplesAccurate diagnosisPremature closurePublic healthTherapyNumerous reportsDiagnosisPatientsPrognosisIgMWorkupInfectionCliniciansCytomegalovirus appendicitis in an immunocompetent host
Canterino JE, McCormack M, Gurung A, Passarelli J, Landry ML, Golden M. Cytomegalovirus appendicitis in an immunocompetent host. Journal Of Clinical Virology 2016, 78: 9-11. PMID: 26942831, DOI: 10.1016/j.jcv.2016.02.011.Peer-Reviewed Case Reports and Technical NotesConceptsImmune-compromising conditionsEnd-organ diseaseCommon viral pathogensCMV appendicitisCytomegalovirus appendicitisMononucleosis syndromeImmunocompetent hostsImmunocompetent individualsAsymptomatic infectionCommon manifestationHealthy individualsViral pathogensAppendicitisCytomegalovirusPatientsSyndromeInfectionDiseaseIndividuals
2015
Toscana Virus Encephalitis in a Traveler Returning to the United States
Howell BA, Azar MM, Landry ML, Shaw AC. Toscana Virus Encephalitis in a Traveler Returning to the United States. Journal Of Clinical Microbiology 2015, 53: 1445-1447. PMID: 25673791, PMCID: PMC4365192, DOI: 10.1128/jcm.03498-14.Peer-Reviewed Case Reports and Technical Notes
2013
Hepatitis E virus infection in a liver transplant recipient: delayed diagnosis due to variable performance of serologic assays
Yoo N, Bernstein J, Caldwell C, Dong C, Drobeniuc J, Kamili S, Landry ML. Hepatitis E virus infection in a liver transplant recipient: delayed diagnosis due to variable performance of serologic assays. Transplant Infectious Disease 2013, 15: e166-e168. PMID: 23701647, DOI: 10.1111/tid.12096.Peer-Reviewed Original Research
2010
Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Infections in Healthy Adults
Sabetta JR, DePetrillo P, Cipriani RJ, Smardin J, Burns LA, Landry ML. Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Infections in Healthy Adults. PLOS ONE 2010, 5: e11088. PMID: 20559424, PMCID: PMC2885414, DOI: 10.1371/journal.pone.0011088.Peer-Reviewed Original ResearchConceptsAcute viral respiratory tract infectionsViral respiratory tract infectionsRespiratory tract infectionsAcute respiratory tract infectionsTract infectionsD concentrationsVitamin DSerum concentrationsViral infectionHealthy adultsVitamin D supplementationD serum concentrationsBurden of illnessFuture interventional studiesIncidence of infectionSpecific viral infectionsLean body massPrevalence of influenzaPercentage of daysDark-skinned individualsD supplementationPregnant womenInterventional studyGeneral populationInfection
2009
WU Polyomavirus in Patients Infected with HIV or Hepatitis C Virus, Connecticut, USA, 2007 - Volume 15, Number 7—July 2009 - Emerging Infectious Diseases journal - CDC
Miller MA, Weibel C, Ferguson D, Landry ML, Kahn JS. WU Polyomavirus in Patients Infected with HIV or Hepatitis C Virus, Connecticut, USA, 2007 - Volume 15, Number 7—July 2009 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2009, 15: 1095-1097. PMID: 19624928, PMCID: PMC2744261, DOI: 10.3201/eid1507.090150.Peer-Reviewed Original ResearchAdenovirus type 3 outbreak in connecticut associated with a novel variant
Landry ML, Lebeck MG, Capuano AW, McCarthy T, Gray GC. Adenovirus type 3 outbreak in connecticut associated with a novel variant. Journal Of Medical Virology 2009, 81: 1380-1384. PMID: 19551823, PMCID: PMC2897138, DOI: 10.1002/jmv.21539.Peer-Reviewed Original ResearchRhinoviruses Are a Major Cause of Wheezing and Hospitalization in Children Less Than 2 Years of Age
Piotrowska Z, Vázquez M, Shapiro ED, Weibel C, Ferguson D, Landry ML, Kahn JS. Rhinoviruses Are a Major Cause of Wheezing and Hospitalization in Children Less Than 2 Years of Age. The Pediatric Infectious Disease Journal 2009, 28: 25-29. PMID: 19057454, PMCID: PMC4639321, DOI: 10.1097/inf.0b013e3181861da0.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusHRV-positive childrenHuman rhinovirusSyncytial virusAge groupsDiagnostic laboratoriesRespiratory tract diseaseMajor respiratory pathogenRate of infectionYears of ageSimilar age groupAsymptomatic childrenRespiratory specimenAsymptomatic groupRespiratory infectionsHRV infectionHospitalization ratesPolymerase chain reactionTract diseaseRespiratory pathogensHRV isolatesMajor causeStudy periodSymptomsInfection
2008
Parvovirus
Landry M. Parvovirus. 2008, 183-193. DOI: 10.1128/9781555815455.ch9.Peer-Reviewed Original ResearchParvovirus B19 infectionParvovirus B19B19 infectionChronic fatigue syndromeTreatable causeAcute infectionChronic anemiaFatigue syndromeImmunocompetent hostsHuman bocavirusNeurologic syndromeIgG antibodiesCerebrospinal fluidRenal syndromeImmunoglobulin MBone marrowInfectionSyndromeB19Parvoviridae familyParvovirusHuman diseasesMinute virusVasculitisUveitisAn Outbreak of Concurrent Echovirus 30 and Coxsackievirus A1 Infections Associated with Sea Swimming among a Group of Travelers to Mexico
Begier EM, Oberste MS, Landry ML, Brennan T, Mlynarski D, Mshar PA, Frenette K, Rabatsky-Ehr T, Purviance K, Nepaul A, Nix WA, Pallansch MA, Ferguson D, Cartter ML, Hadler JL. An Outbreak of Concurrent Echovirus 30 and Coxsackievirus A1 Infections Associated with Sea Swimming among a Group of Travelers to Mexico. Clinical Infectious Diseases 2008, 47: 616-623. PMID: 18637756, DOI: 10.1086/590562.Peer-Reviewed Original ResearchConceptsEchovirus 30Enteroviral infectionNucleic acid amplification testingIllness onset datesUninfected control subjectsPoint-source exposureMultiple enterovirusesAseptic meningitisFrequent symptomsIllness onsetViral cultureAmplification testingControl subjectsCerebrospinal fluidHuman stoolInfectionNauseaConnecticut DepartmentStoolCoxsackievirus (CV) A1Public healthIllnessEnterovirusesMolecular amplificationGroups of travelers
2007
Genotype Prevalence and Risk Factors for Severe Clinical Adenovirus Infection, United States 2004–2006
Gray GC, McCarthy T, Lebeck MG, Schnurr DP, Russell KL, Kajon AE, Landry ML, Leland DS, Storch GA, Ginocchio CC, Robinson CC, Demmler GJ, Saubolle MA, Kehl SC, Selvarangan R, Miller MB, Chappell JD, Zerr DM, Kiska DL, Halstead DC, Capuano AW, Setterquist SF, Chorazy ML, Dawson JD, Erdman DD. Genotype Prevalence and Risk Factors for Severe Clinical Adenovirus Infection, United States 2004–2006. Clinical Infectious Diseases 2007, 45: 1120-1131. PMID: 17918073, PMCID: PMC2064001, DOI: 10.1086/522188.Peer-Reviewed Original ResearchConceptsAdenovirus infectionIntensive care unit staySolid organ transplantationChronic disease conditionsAdenovirus isolatesUnited States 2004Adenovirus-positive specimensRisk factor modelingTyping methodsUnit stayRisk factorsAntigenic presentationChronic diseasesGenotype prevalenceClinical dataOrgan transplantationSevere diseaseRecent transplantationBone marrowBlinded comparisonDisease severityMilitary traineesSequence typing methodInfectionCancer diagnosisSerum IgA Antibodies to Epstein-Barr Virus (EBV) Early Lytic Antigens Are Present in Primary EBV Infection
Bhaduri-McIntosh S, Landry ML, Nikiforow S, Rotenberg M, El-Guindy A, Miller G. Serum IgA Antibodies to Epstein-Barr Virus (EBV) Early Lytic Antigens Are Present in Primary EBV Infection. The Journal Of Infectious Diseases 2007, 195: 483-492. PMID: 17230407, DOI: 10.1086/510916.Peer-Reviewed Original ResearchConceptsPrimary EBV infectionSerum IgA antibodiesIgA antibodiesEBV infectionLytic antigensPrimary infectionPrimary Epstein-Barr virus infectionHealthy EBV-seropositive individualsEpstein-Barr virus infectionEB nuclear antigenEBV-seropositive individualsViral capsid antigenAbsence of antibodiesFlow cytometry-based assayLytic EBV replicationCytometry-based assayBurkitt's lymphoma cellsCapsid antigenMucosal sitesEBV replicationIgM antibodiesVirus infectionInfectionLymphoma cellsSerum samples
2006
Coronavirus HKU1 Infection in the United States
Esper F, Weibel C, Ferguson D, Landry ML, Kahn JS. Coronavirus HKU1 Infection in the United States. Emerging Infectious Diseases 2006, 12: 775-779. PMID: 16704837, PMCID: PMC3374449, DOI: 10.3201/eid1205.051316.Peer-Reviewed Original ResearchConceptsHCoV-HKU1Respiratory specimensLower respiratory tract infectionsLower respiratory tract diseaseHCoV-HKU1 infectionRespiratory tract infectionsRespiratory syncytial virusRespiratory tract diseaseReverse transcription-polymerase chain reactionNew human coronavirusYears of ageTranscription-polymerase chain reactionTract infectionsSyncytial virusPositive childrenParainfluenza virusTract diseaseRespiratory tractHuman coronavirusesPositive specimensInfluenza virusInfectionChain reactionChildrenVirus