Systematic identification of biomarker-driven drug combinations to overcome resistance
Rees M, Brenan L, do Carmo M, Duggan P, Bajrami B, Arciprete M, Boghossian A, Vaimberg E, Ferrara S, Lewis T, Rosenberg D, Sangpo T, Roth J, Kaushik V, Piccioni F, Doench J, Root D, Johannessen C. Systematic identification of biomarker-driven drug combinations to overcome resistance. Nature Chemical Biology 2022, 18: 615-624. PMID: 35332332, DOI: 10.1038/s41589-022-00996-7.Peer-Reviewed Original ResearchConceptsSmall molecule responsesCell linesGSK-J4Gene expression featuresMonoacylglycerol lipaseGene knockoutSerine hydrolaseCancer cell linesSystematic identificationCell viability profileInsensitive cell linesNovel relationshipSmall moleculesMechanism of actionEnzymatic modificationSpecific mechanismsViability profileIntrinsic resistanceVariable responseMechanistic studiesRational candidatesMechanism