2000
Effects of Lamotrigine on Behavioral and Cardiovascular Responses to Cocaine in Human Subjects
Winther L, Saleem R, McCance-Katz E, Rosen M, Hameedi F, Pearsall H, Jatlow P, Kosten T, Woods S. Effects of Lamotrigine on Behavioral and Cardiovascular Responses to Cocaine in Human Subjects. The American Journal Of Drug And Alcohol Abuse 2000, 26: 47-59. PMID: 10718163, DOI: 10.1081/ada-100100590.Peer-Reviewed Original ResearchConceptsBlood pressureHeart rateGlutamate release inhibitorEffects of lamotrigineCocaine-dependent volunteersMood States questionnaireLamotrigine pretreatmentAcute pretreatmentCardiovascular responsesRelaxing effectRelease inhibitorIntranasal cocaineStudy daysDrug effectsLamotriginePredetermined time intervalsCocainePlaceboHuman subjectsState QuestionnaireExperimental sessionsSubjectsMood effectsBehavioral responsesSubjective ratings
1996
Effect of clonidine pretreatment on naloxone-precipitated opiate withdrawal.
Rosen M, McMahon T, Hameedi F, Pearsall H, Woods S, Kreek M, Kosten T. Effect of clonidine pretreatment on naloxone-precipitated opiate withdrawal. Journal Of Pharmacology And Experimental Therapeutics 1996, 276: 1128-35. PMID: 8786543.Peer-Reviewed Original ResearchConceptsClonidine pretreatmentOpiate withdrawalAdrenocorticotropic hormone (ACTH) responseDiastolic blood pressureNaloxone-precipitated opiate withdrawalNaloxone challenge testHeroin-dependent subjectsMeasures of withdrawalNasal congestionBlood pressureNew medicationsWithdrawal severityTesting medicationsChallenge testPlasma cortisolHormone responseConsecutive daysPilot studyClonidineMedicationsPositive controlWithdrawalBase linePretreatmentTwo-factor analysisGender differences in response to intranasal cocaine administration to humans
Kosten T, Kosten T, McDougle C, Hameedi F, McCance E, Rosen M, Oliveto A, Price L. Gender differences in response to intranasal cocaine administration to humans. Biological Psychiatry 1996, 39: 147-148. PMID: 8717615, DOI: 10.1016/0006-3223(95)00386-x.Peer-Reviewed Original Research
1995
Opiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT)
Krystal J, Woods S, Kosten T, Rosen M, Seibyl J, Van Dyck C, Price L, Zubal I, Hoffer P, Charney D. Opiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT). The American Journal Of Drug And Alcohol Abuse 1995, 21: 47-63. PMID: 7762544, DOI: 10.3109/00952999509095229.Peer-Reviewed Original ResearchConceptsRegional brain functionOpiate withdrawal signsSingle Photon Emission Computerized TomographyHealthy subjectsNaloxone administrationOpiate withdrawalOpiate dependenceBrain functionParietal cortexHexamethylpropyleneamine oximeWithdrawal signsNaloxone effectChronic opiate dependencePlacebo-controlled studyRegional alterationsComparison of patientsMethadone-maintained patientsRegional cerebral perfusionPhoton Emission Computerized TomographyOpiate-dependent patientsRight temporal cortexRight parietal cortexFunctional brain imaging technologiesSingle photon emissionEmission computerized tomographyReliability of Sequential Naloxone Challenge Tests
Rosen M, McMahon T, Margolin A, Gill T, Woods S, Pearsall H, Kreek M, Kosten T. Reliability of Sequential Naloxone Challenge Tests. The American Journal Of Drug And Alcohol Abuse 1995, 21: 453-467. PMID: 8561097, DOI: 10.3109/00952999509002710.Peer-Reviewed Original ResearchDiscriminative stimulus, self-reported and cardiovascular effects of orally administered cocaine in humans.
Oliveto A, Rosen M, Woods S, Kosten T. Discriminative stimulus, self-reported and cardiovascular effects of orally administered cocaine in humans. Journal Of Pharmacology And Experimental Therapeutics 1995, 272: 231-41. PMID: 7815337.Peer-Reviewed Original ResearchConceptsDose-effect curve determinationsPlacebo-appropriate respondingDose-related increaseCocaine-appropriate respondingCocaine-abusing volunteersDose-effect curvesBlood pressureCardiovascular effectsOral doseIntranasal routeIntranasal cocaineCocaine dosesHeart rateTraining doseBenzodiazepine triazolamPlaceboCocaine HClBehavioral effectsCardiovascular measuresCocaineTriazolamSimilar increaseDiscriminative stimulusDoseSubjects