2000
Effects of Lamotrigine on Behavioral and Cardiovascular Responses to Cocaine in Human Subjects
Winther L, Saleem R, McCance-Katz E, Rosen M, Hameedi F, Pearsall H, Jatlow P, Kosten T, Woods S. Effects of Lamotrigine on Behavioral and Cardiovascular Responses to Cocaine in Human Subjects. The American Journal Of Drug And Alcohol Abuse 2000, 26: 47-59. PMID: 10718163, DOI: 10.1081/ada-100100590.Peer-Reviewed Original ResearchConceptsBlood pressureHeart rateGlutamate release inhibitorEffects of lamotrigineCocaine-dependent volunteersMood States questionnaireLamotrigine pretreatmentAcute pretreatmentCardiovascular responsesRelaxing effectRelease inhibitorIntranasal cocaineStudy daysDrug effectsLamotriginePredetermined time intervalsCocainePlaceboHuman subjectsState QuestionnaireExperimental sessionsSubjectsMood effectsBehavioral responsesSubjective ratings
1999
The effects of naltrexone maintenance on the response to yohimbine in healthy volunteers
Rosen M, Kosten T, Kreek M. The effects of naltrexone maintenance on the response to yohimbine in healthy volunteers. Biological Psychiatry 1999, 45: 1636-1645. PMID: 10376126, DOI: 10.1016/s0006-3223(98)00259-5.Peer-Reviewed Original ResearchConceptsWeeks of treatmentDrug effectsStrongest drug effectsOpioid antagonist naltrexoneActive naltrexoneNaltrexone treatmentNaltrexone maintenanceAntagonist naltrexoneHealthy subjectsHealthy volunteersWeek 1Week 2Cortisol levelsYohimbineWeek 5PlaceboPreclinical researchNaltrexoneAlters sensitivityEffect of pretreatmentWeeksAntagonistTreatmentStress responsivenessSubjects
1998
The effect of lamotrigine on naloxone-precipitated opiate withdrawal
Rosen M, Pearsall H, Kosten T. The effect of lamotrigine on naloxone-precipitated opiate withdrawal. Drug And Alcohol Dependence 1998, 52: 173-176. PMID: 9800147, DOI: 10.1016/s0376-8716(98)00057-x.Peer-Reviewed Original Research
1997
Effects of gamma-hydroxybutyric acid (GHB) in opioid-dependent patients
Rosen M, Pearsall H, Woods S, Kosten T. Effects of gamma-hydroxybutyric acid (GHB) in opioid-dependent patients. Journal Of Substance Use And Addiction Treatment 1997, 14: 149-154. PMID: 9258859, DOI: 10.1016/s0740-5472(96)00157-2.Peer-Reviewed Original ResearchTreatment of Early AIDS Dementia in Intravenous Drug Users: High Versus Low Dose Peptide T
Kosten T, Rosen M, McMahon T, Bridge T, O'malley S, Pearsall R, O'connor P. Treatment of Early AIDS Dementia in Intravenous Drug Users: High Versus Low Dose Peptide T. The American Journal Of Drug And Alcohol Abuse 1997, 23: 543-553. PMID: 9366972, DOI: 10.3109/00952999709016894.Peer-Reviewed Original Research
1996
A pilot study of dextromethorphan in naloxone-precipitated opiate withdrawal
Rosen M, McMahon T, Woods S, Pearsall H, Kosten T. A pilot study of dextromethorphan in naloxone-precipitated opiate withdrawal. European Journal Of Pharmacology 1996, 307: 251-257. PMID: 8836612, DOI: 10.1016/0014-2999(96)00249-x.Peer-Reviewed Original ResearchConceptsNaloxone-precipitated opiate withdrawalOpiate withdrawalOpiate-dependent subjectsPre-clinical studiesConsiderable inter-individual variabilityPretreatment 1 hInter-individual variabilityIntramuscular naloxoneDextromethorphanPilot studyWithdrawal measuresPlaceboNaloxoneMethadoneWithdrawalSubjectsDifferent daysRandomized design
1995
Discriminative stimulus, self-reported and cardiovascular effects of orally administered cocaine in humans.
Oliveto A, Rosen M, Woods S, Kosten T. Discriminative stimulus, self-reported and cardiovascular effects of orally administered cocaine in humans. Journal Of Pharmacology And Experimental Therapeutics 1995, 272: 231-41. PMID: 7815337.Peer-Reviewed Original ResearchConceptsDose-effect curve determinationsPlacebo-appropriate respondingDose-related increaseCocaine-appropriate respondingCocaine-abusing volunteersDose-effect curvesBlood pressureCardiovascular effectsOral doseIntranasal routeIntranasal cocaineCocaine dosesHeart rateTraining doseBenzodiazepine triazolamPlaceboCocaine HClBehavioral effectsCardiovascular measuresCocaineTriazolamSimilar increaseDiscriminative stimulusDoseSubjects