1998
Hydromorphone–Naloxone Combinations in Opioid-Dependent Humans Under a Naloxone Novel-Response Discrimination Procedure
Oliveto A, Rosen M, Kosten T, Hameedi F, Woods S, Kosten T. Hydromorphone–Naloxone Combinations in Opioid-Dependent Humans Under a Naloxone Novel-Response Discrimination Procedure. Experimental And Clinical Psychopharmacology 1998, 6: 169-178. PMID: 9608349, DOI: 10.1037/1064-1297.6.2.169.Peer-Reviewed Original ResearchConceptsNaloxone-appropriate respondingNovel-appropriate respondingDose-related increaseNovel-response drug discrimination procedureOpioid-dependent humansDose-related decreaseDrug discrimination procedureHuman laboratory modelOpioid withdrawalDiscrimination procedureNaloxoneHydromorphoneNonhuman dataAppropriate respondingRespondingPlaceboMethadone
1995
Discriminative stimulus, self-reported and cardiovascular effects of orally administered cocaine in humans.
Oliveto A, Rosen M, Woods S, Kosten T. Discriminative stimulus, self-reported and cardiovascular effects of orally administered cocaine in humans. Journal Of Pharmacology And Experimental Therapeutics 1995, 272: 231-41. PMID: 7815337.Peer-Reviewed Original ResearchConceptsDose-effect curve determinationsPlacebo-appropriate respondingDose-related increaseCocaine-appropriate respondingCocaine-abusing volunteersDose-effect curvesBlood pressureCardiovascular effectsOral doseIntranasal routeIntranasal cocaineCocaine dosesHeart rateTraining doseBenzodiazepine triazolamPlaceboCocaine HClBehavioral effectsCardiovascular measuresCocaineTriazolamSimilar increaseDiscriminative stimulusDoseSubjects