2024
Pragmatic clinical trials as hybrid effectiveness-implementation studies to shrink the evidence-to-practice gap for chronic pain management
Midboe A, Seal K, Burgess D, Rosen M, Martino S. Pragmatic clinical trials as hybrid effectiveness-implementation studies to shrink the evidence-to-practice gap for chronic pain management. Pain Medicine 2024, 25: s77-s79. PMID: 39514879, PMCID: PMC11548854, DOI: 10.1093/pm/pnae067.Peer-Reviewed Original ResearchImpact of the COVID-19 pandemic on participants in pragmatic clinical trials for chronic pain: implications for trial outcomes and beyond
Sellinger J, Gilstad-Hayden K, Lazar C, Seal K, Purcell N, Burgess D, Martino S, Heapy A, Higgins D, Rosen M. Impact of the COVID-19 pandemic on participants in pragmatic clinical trials for chronic pain: implications for trial outcomes and beyond. Pain Medicine 2024, 25: s17-s27. PMID: 39514885, PMCID: PMC11548862, DOI: 10.1093/pm/pnae060.Peer-Reviewed Original ResearchConceptsPragmatic clinical trialsHealth careSocial supportChronic painEmotional healthHigher levels of painPain Management CollaboratoryEffective pain managementClinical trialsLevel of painEffectiveness of treatment outcomesPandemic impactAlcohol use disorder screeningCOVID-19-related impactsCOVID-19 pandemicChronic pain treatmentMental healthPain managementDisorder screeningNonpharmacological treatmentsPain treatmentStudy enrollmentCOVID-19HealthCareSensitivity, specificity, and discordance with self-report of nail sample testing for alcohol and cannabis
Morie K, Gilstad-Hayden K, Martino S, Lazar C, Rosen M. Sensitivity, specificity, and discordance with self-report of nail sample testing for alcohol and cannabis. Drug And Alcohol Dependence 2024, 261: 111358. PMID: 38943713, DOI: 10.1016/j.drugalcdep.2024.111358.Peer-Reviewed Original ResearchDelta 9-THCAlcohol-related problemsRisky alcohol useSelf-reportAlcohol useEthyl glucuronideAUDIT-CAlcohol use patternsSelf-reported alcoholInaccurate self-reportsSubstance use patternsFactors associated with discordanceSubstance-related harmsMarijuana problemsNail clippingsCannabis metabolitesNon-Hispanic ethnicityStandard cut-offsMarijuana useClinical trialsCannabisAlcohol metabolitesWhite raceTelephone questionnaireHighest specificity
2023
Adherence to Antiretrovirals and HIV Viral Suppression Under COVID-19 Pandemic Interruption – Findings from a Randomized Clinical Trial Using Ingestible Sensors to Monitor Adherence
Wang Y, Daar E, Huang Y, Xiong D, Shen J, Zhou L, Siqueiros L, Guerrero M, Rosen M, Liu H. Adherence to Antiretrovirals and HIV Viral Suppression Under COVID-19 Pandemic Interruption – Findings from a Randomized Clinical Trial Using Ingestible Sensors to Monitor Adherence. AIDS And Behavior 2023, 27: 4041-4051. PMID: 37401993, PMCID: PMC10598162, DOI: 10.1007/s10461-023-04118-9.Peer-Reviewed Original ResearchConceptsLog viral loadViral loadClinical trialsHIV RNA viral loadUsual care groupHIV viral suppressionRNA viral loadRandomized clinical trialsSelf-reported adherenceLongitudinal mixed effects modelsViral suppressionClinical outcomesCare groupWeek 28Week 16Intervention groupAntiretroviralsIntervention effectsVulnerable populationsAdherenceMixed effects modelsRandom interceptRetention rateCOVID-19 pandemicIngestible sensor
2021
Optimizing the Impact of Pragmatic Clinical Trials for Veteran and Military Populations: Lessons From the Pain Management Collaboratory
Ali J, Antonelli M, Bastian L, Becker W, Brandt CA, Burgess DJ, Burns A, Cohen SP, Davis AF, Dearth CL, Dziura J, Edwards R, Erdos J, Farrokhi S, Fritz J, Geda M, George SZ, Goertz C, Goodie J, Hastings SN, Heapy A, Ilfeld BM, Katsovich L, Kerns RD, Kyriakides TC, Lee A, Long CR, Luther SL, Martino S, Matheny ME, McGeary D, Midboe A, Pasquina P, Peduzzi P, Raffanello M, Rhon D, Rosen M, Esposito ER, Scarton D, Hastings SN, Seal K, Silliker N, Taylor S, Taylor SL, Tsui M, Wright FS, Zeliadt S. Optimizing the Impact of Pragmatic Clinical Trials for Veteran and Military Populations: Lessons From the Pain Management Collaboratory. Military Medicine 2021, 187: 179-185. PMID: 34791412, PMCID: PMC9389906, DOI: 10.1093/milmed/usab458.Peer-Reviewed Original ResearchConceptsPragmatic clinical trialsPain Management CollaboratoryClinical trialsMultisite pragmatic clinical trialManagement of painDual public health crisesCommon co-occurring conditionsPragmatic trial designUnmet healthcare needsMilitary Health SystemCo-occurring conditionsPublic health crisisPain managementChronic painNonpharmacological approachesOpioid misuseMultifactorial etiologyTrial designVeterans AffairsMilitary populationHealthcare needsHealth systemNational InstitutePainCOVID-19 pandemic
2020
Pilot Clinical Trial of a Website-Delivered Motivational Interviewing Program for Engaging Veterans in Paid Work
Lazar C, Gilstad-Hayden K, Brummett B, Simon P, Kachadourian L, Rosen M. Pilot Clinical Trial of a Website-Delivered Motivational Interviewing Program for Engaging Veterans in Paid Work. American Journal Of Psychiatric Rehabilitation 2020, 23: 201-226. DOI: 10.1353/jpr.2020.0011.Peer-Reviewed Original ResearchService-connectedControl websiteCounseling interventionVeterans AdministrationMotivational interviewing programMental health conditionsWeb-based adaptationWork-related activitiesVA benefitsBenefits counselingHealth conditionsPaid workEmployment outcomesVeteransCounseling programInterview programCounselingInterventionParticipantsPilot clinical trialEmploymentWebsitesProgramClinical trialsBenefits
2018
Veterans’ compensation claims beliefs predict timing of PTSD treatment use relative to compensation and pension exam
Black AC, Meshberg-Cohen S, Perez-Ortiz AC, Thornhill TA, Rosen MI. Veterans’ compensation claims beliefs predict timing of PTSD treatment use relative to compensation and pension exam. PLOS ONE 2018, 13: e0209488. PMID: 30589882, PMCID: PMC6307722, DOI: 10.1371/journal.pone.0209488.Peer-Reviewed Original ResearchConceptsMental health treatment useTreatment useMental health treatmentExamination statusPTSD treatmentTreatment benefitVeterans' useHealth treatmentEffective PTSD treatmentPTSD treatment engagementElectronic health recordsClinical trialsTreatment engagementBaseline assessmentCompensation examinationsHealth recordsPension examinationsVeterans' beliefsTreatmentVeteransBeliefs ScalePTSDDisability-related benefitsExaminationStatus
2014
Work Outcomes After Benefits Counseling Among Veterans Applying for Service Connection for a Psychiatric Condition
Rosen MI, Ablondi K, Black AC, Mueller L, Serowik KL, Martino S, Mobo BH, Rosenheck RA. Work Outcomes After Benefits Counseling Among Veterans Applying for Service Connection for a Psychiatric Condition. Psychiatric Services 2014, 65: 1426-1432. PMID: 25082304, PMCID: PMC4713007, DOI: 10.1176/appi.ps.201300478.Peer-Reviewed Original ResearchConceptsClinical trialsSix monthsPsychiatric conditionsVeterans Affairs Health Care SystemDisability paymentsMore daysMental health servicesHealth care systemTimeline FollowPsychiatric disordersBasic counselingControl groupHealth servicesBenefits counselingWork-related activitiesCare systemCounselingVeteransStudy objectiveDisability benefitsTrialsDaysControl conditionMore researchActive ingredients
1992
Peptide T Treatment of Cognitive Impairment in HIV‐Positive Intravenous Drug Users
Rosen M, Bridge T, O'Malley S, Pearsall H, Martini B, O'Connor P, Brett‐Smith H, Thomas H, Van Dyck C, Woods S, Kosten T. Peptide T Treatment of Cognitive Impairment in HIV‐Positive Intravenous Drug Users. American Journal On Addictions 1992, 1: 332-338. DOI: 10.1111/j.1521-0391.1992.tb00359.x.Peer-Reviewed Original ResearchHIV-positive intravenous drug usersDouble-blind crossover studyPeptide T treatmentHIV-positive patientsPeptide TOpen clinical trialIntravenous drug usersVasoactive intestinal peptideAIDS dementiaCrossover studyNeuropsychological improvementAZT treatmentIntestinal peptideClinical trialsDrug usersCognitive impairmentPatientsNeuropsychological functionCognitive functionT treatmentPlaceboThree timesWeeksPotential utilityTreatmentBuprenorphine for cocaine and opiate dependence.
Kosten T, Rosen M, Schottenfeld R, Ziedonis D. Buprenorphine for cocaine and opiate dependence. Psychopharmacology Bulletin 1992, 28: 15-9. PMID: 1609037.Peer-Reviewed Original ResearchConceptsCocaine abuseMixed opioid agonist/antagonistOpioid agonist/antagonistPreliminary human studiesAgonists/antagonistsBuprenorphine treatmentOpioid dependenceMethadone maintenanceClinical trialsConcurrent dependencePreclinical studiesCocaine effectsBuprenorphineHuman studiesPlace preferenceChallenge studiesCocaineMethadoneTreatmentTrialsAbuseDose dependenceOpioidsAntagonistDaily