2000
Significant interaction between clozapine and cocaine in cocaine addicts
Farren C, Hameedi F, Rosen M, Woods S, Jatlow P, Kosten T. Significant interaction between clozapine and cocaine in cocaine addicts. Drug And Alcohol Dependence 2000, 59: 153-163. PMID: 10891628, DOI: 10.1016/s0376-8716(99)00114-3.Peer-Reviewed Original ResearchConceptsSerum cocaine levelsCocaine levelsClozapine pretreatmentIntranasal cocaineBaseline pulse rateNear-syncopal eventsSignificant pressor effectSystolic blood pressureDoses of clozapinePossible therapeutic roleDose-dependent mannerMale cocainePressor effectSyncopal episodesBlood pressureOral challengeSingle doseBlood levelsTherapeutic roleClozapineCocaine addictionPulse rateCocaineDoseDependent mannerEffects of Lamotrigine on Behavioral and Cardiovascular Responses to Cocaine in Human Subjects
Winther L, Saleem R, McCance-Katz E, Rosen M, Hameedi F, Pearsall H, Jatlow P, Kosten T, Woods S. Effects of Lamotrigine on Behavioral and Cardiovascular Responses to Cocaine in Human Subjects. The American Journal Of Drug And Alcohol Abuse 2000, 26: 47-59. PMID: 10718163, DOI: 10.1081/ada-100100590.Peer-Reviewed Original ResearchConceptsBlood pressureHeart rateGlutamate release inhibitorEffects of lamotrigineCocaine-dependent volunteersMood States questionnaireLamotrigine pretreatmentAcute pretreatmentCardiovascular responsesRelaxing effectRelease inhibitorIntranasal cocaineStudy daysDrug effectsLamotriginePredetermined time intervalsCocainePlaceboHuman subjectsState QuestionnaireExperimental sessionsSubjectsMood effectsBehavioral responsesSubjective ratings
1996
Effect of clonidine pretreatment on naloxone-precipitated opiate withdrawal.
Rosen M, McMahon T, Hameedi F, Pearsall H, Woods S, Kreek M, Kosten T. Effect of clonidine pretreatment on naloxone-precipitated opiate withdrawal. Journal Of Pharmacology And Experimental Therapeutics 1996, 276: 1128-35. PMID: 8786543.Peer-Reviewed Original ResearchConceptsClonidine pretreatmentOpiate withdrawalAdrenocorticotropic hormone (ACTH) responseDiastolic blood pressureNaloxone-precipitated opiate withdrawalNaloxone challenge testHeroin-dependent subjectsMeasures of withdrawalNasal congestionBlood pressureNew medicationsWithdrawal severityTesting medicationsChallenge testPlasma cortisolHormone responseConsecutive daysPilot studyClonidineMedicationsPositive controlWithdrawalBase linePretreatmentTwo-factor analysis
1995
Discriminative stimulus, self-reported and cardiovascular effects of orally administered cocaine in humans.
Oliveto A, Rosen M, Woods S, Kosten T. Discriminative stimulus, self-reported and cardiovascular effects of orally administered cocaine in humans. Journal Of Pharmacology And Experimental Therapeutics 1995, 272: 231-41. PMID: 7815337.Peer-Reviewed Original ResearchConceptsDose-effect curve determinationsPlacebo-appropriate respondingDose-related increaseCocaine-appropriate respondingCocaine-abusing volunteersDose-effect curvesBlood pressureCardiovascular effectsOral doseIntranasal routeIntranasal cocaineCocaine dosesHeart rateTraining doseBenzodiazepine triazolamPlaceboCocaine HClBehavioral effectsCardiovascular measuresCocaineTriazolamSimilar increaseDiscriminative stimulusDoseSubjectsReliability of Sequential Naloxone Challenge Tests
Rosen M, McMahon T, Margolin A, Gill T, Woods S, Pearsall H, Kreek M, Kosten T. Reliability of Sequential Naloxone Challenge Tests. The American Journal Of Drug And Alcohol Abuse 1995, 21: 453-467. PMID: 8561097, DOI: 10.3109/00952999509002710.Peer-Reviewed Original Research