Neural mechanisms linked to treatment outcomes and recovery in substance-related and addictive disorders
Mestre-Bach G, Potenza M. Neural mechanisms linked to treatment outcomes and recovery in substance-related and addictive disorders. Dialogues In Clinical Neuroscience 2023, 25: 75-91. PMID: 37594217, PMCID: PMC10444012, DOI: 10.1080/19585969.2023.2242359.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsBehavior, AddictiveBrainHumansInternet Addiction DisorderMental DisordersTreatment OutcomeConceptsNeural mechanismsAddictive disordersPotential neural mechanismsTreatment development effortsInternet gaming disorderBrain processesSubstance use disordersAdvanced analytic approachesGaming disorderImpulse controlTreatment developmentUse disordersPsychiatric conditionsExtant dataTreatment utilityAddictionDisordersAnalytic approachTreatment outcomesNarrative reviewIntervention administrationMedication challengePresent reviewMain modelsContextYouth Screen Media Activity Patterns and Associations With Behavioral Developmental Measures and Resting-state Brain Functional Connectivity
Song K, Zhang J, Zhou N, Fu Y, Zou B, Xu L, Wang Z, Li X, Zhao Y, Potenza M, Fang X, Zhang J. Youth Screen Media Activity Patterns and Associations With Behavioral Developmental Measures and Resting-state Brain Functional Connectivity. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 62: 1051-1063. PMID: 36963562, PMCID: PMC10509312, DOI: 10.1016/j.jaac.2023.02.014.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAgedAged, 80 and overBrainChildCognitionConnectomeFemaleHumansMagnetic Resonance ImagingMaleMental DisordersConceptsBrain functional connectivityResting-state brain functional connectivityDevelopmental measuresFunctional connectivityHuman participantsTotal behavioral problemsPsychotic-like experiencesPoorer neurocognitive performanceHuman Connectome ProjectCognitive processesAdolescent brainYouth developmentABCD dataHigh impulsivityNeurocognitive performanceBrain measuresPunishment/Behavioral problemsConnectome ProjectLate childhoodLinear mixed effectsBrain areasYouth lifeIndependent samplesParticipantsUse of experimental medicine approaches for the development of novel psychiatric treatments based on orexin receptor modulation
Beckenstrom A, Coloma P, Dawson G, Finlayson A, Malik A, Post A, Steiner M, Potenza M. Use of experimental medicine approaches for the development of novel psychiatric treatments based on orexin receptor modulation. Neuroscience & Biobehavioral Reviews 2023, 147: 105107. PMID: 36828161, PMCID: PMC10165155, DOI: 10.1016/j.neubiorev.2023.105107.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsExperimental medicine approachPerformance outcome measuresPsychiatric disordersMedicine approachReal-world clinical practiceOrexin neuropeptide systemMarkers of efficacyPatient advocacy groupsOrexin modulationReceptor modulationSymptom evaluationReceptor modulatorsClinical studiesMood disordersPreclinical studiesNeuropeptide systemsPsychiatric treatmentAnimal modelsPathological mechanismsClinical practiceClinical researchClinical useBrain functionTranslational researchPotential target