2009
Arterial transit time effects in pulsed arterial spin labeling CBF mapping: Insight from a PET and MR study in normal human subjects
Qiu M, Maguire R, Arora J, Planeta‐Wilson B, Weinzimmer D, Wang J, Wang Y, Kim H, Rajeevan N, Huang Y, Carson RE, Constable RT. Arterial transit time effects in pulsed arterial spin labeling CBF mapping: Insight from a PET and MR study in normal human subjects. Magnetic Resonance In Medicine 2009, 63: 374-384. PMID: 19953506, PMCID: PMC2867043, DOI: 10.1002/mrm.22218.Peer-Reviewed Original ResearchFunctional connectivity and alterations in baseline brain state in humans
Martuzzi R, Ramani R, Qiu M, Rajeevan N, Constable RT. Functional connectivity and alterations in baseline brain state in humans. NeuroImage 2009, 49: 823-834. PMID: 19631277, PMCID: PMC2764802, DOI: 10.1016/j.neuroimage.2009.07.028.Peer-Reviewed Original ResearchConceptsDefault mode networkMAC sevoflurane anesthesiaBaseline brain activityFunctional connectivity fMRISevoflurane anesthesiaHigher-order brain regionsAnesthetized conditionSensory cortexDifferent brain networksBaseline activityBrain regionsHuman volunteersSensory areasFunctional connectivityAnesthesiaMode networkLow-level sensory areasBrain networksBrain activityCognitive regionsBrain propertiesBrain statesFurther evidencePainThalamus
2008
Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects
Qiu M, Ramani R, Swetye M, Rajeevan N, Constable RT. Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects. Magnetic Resonance In Medicine 2008, 60: 987-996. PMID: 18816821, PMCID: PMC2716171, DOI: 10.1002/mrm.21759.Peer-Reviewed Original ResearchConceptsCerebral blood flowLow-dose sevofluraneRegional cerebral blood flowTask-induced changesBaseline cerebral blood flowBlood oxygen level-dependent (BOLD) signalAbsence of anesthesiaHealthy human subjectsHuman subjectsNormal human subjectsLevel-dependent signalFunctional MR imagingVascular measuresAnesthetic agentsBlood flowAnesthetic effectSevofluraneFunctional MRI dataAnesthesia conditionsAnesthesiaMR imagingAuditory regionsOxidative metabolismAuditory stimuliFMRI study
2007
Sevoflurane 0.25 MAC Preferentially Affects Higher Order Association Areas: A Functional Magnetic Resonance Imaging Study in Volunteers
Ramani R, Qiu M, Constable RT. Sevoflurane 0.25 MAC Preferentially Affects Higher Order Association Areas: A Functional Magnetic Resonance Imaging Study in Volunteers. Anesthesia & Analgesia 2007, 105: 648-655. PMID: 17717218, PMCID: PMC2716177, DOI: 10.1213/01.ane.0000277496.12747.29.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowFunctional magnetic resonance imagingMAC sevofluraneMotor activation taskAssociation cortexMemory-related regionsAssociation areasVolatile anestheticsVisual cortexBaseline regional cerebral blood flowHigher-order association areasMagnetic resonance imaging studyHigher-order association corticesCerebral blood flowActivation taskSupplementary motor areaPrimary cortical regionsSecondary visual cortexPrimary visual cortexResonance imaging studyFunctional magnetic resonance imaging studyMagnetic resonance imagingArterial spin labeling techniqueASA ISubanesthetic doses
2006
Neural correlates of epigenesis
Canli T, Qiu M, Omura K, Congdon E, Haas BW, Amin Z, Herrmann MJ, Constable RT, Lesch KP. Neural correlates of epigenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 16033-16038. PMID: 17032778, PMCID: PMC1592642, DOI: 10.1073/pnas.0601674103.Peer-Reviewed Original ResearchConceptsLife stressSerotonin transporter genotypeTransporter genotypeNeural mechanismsHistory of psychopathologyUnderlying neural mechanismsSerotonin transporter geneFunctional MRIFunctional connectivityMagnetic resonance-based imagingPerfusion dataSelf-reported life stressDepressionEpigenetic vulnerabilityNeural correlates