2009
Functional connectivity and alterations in baseline brain state in humans
Martuzzi R, Ramani R, Qiu M, Rajeevan N, Constable RT. Functional connectivity and alterations in baseline brain state in humans. NeuroImage 2009, 49: 823-834. PMID: 19631277, PMCID: PMC2764802, DOI: 10.1016/j.neuroimage.2009.07.028.Peer-Reviewed Original ResearchConceptsDefault mode networkMAC sevoflurane anesthesiaBaseline brain activityFunctional connectivity fMRISevoflurane anesthesiaHigher-order brain regionsAnesthetized conditionSensory cortexDifferent brain networksBaseline activityBrain regionsHuman volunteersSensory areasFunctional connectivityAnesthesiaMode networkLow-level sensory areasBrain networksBrain activityCognitive regionsBrain propertiesBrain statesFurther evidencePainThalamus
2008
Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects
Qiu M, Ramani R, Swetye M, Rajeevan N, Constable RT. Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects. Magnetic Resonance In Medicine 2008, 60: 987-996. PMID: 18816821, PMCID: PMC2716171, DOI: 10.1002/mrm.21759.Peer-Reviewed Original ResearchConceptsCerebral blood flowLow-dose sevofluraneRegional cerebral blood flowTask-induced changesBaseline cerebral blood flowBlood oxygen level-dependent (BOLD) signalAbsence of anesthesiaHealthy human subjectsHuman subjectsNormal human subjectsLevel-dependent signalFunctional MR imagingVascular measuresAnesthetic agentsBlood flowAnesthetic effectSevofluraneFunctional MRI dataAnesthesia conditionsAnesthesiaMR imagingAuditory regionsOxidative metabolismAuditory stimuliFMRI study
2007
Spatial nonuniformity of the resting CBF and BOLD responses to sevoflurane: In vivo study of normal human subjects with magnetic resonance imaging
Qiu M, Ramani R, Swetye M, Constable RT. Spatial nonuniformity of the resting CBF and BOLD responses to sevoflurane: In vivo study of normal human subjects with magnetic resonance imaging. Human Brain Mapping 2007, 29: 1390-1399. PMID: 17948882, PMCID: PMC2716174, DOI: 10.1002/hbm.20472.Peer-Reviewed Original ResearchSevoflurane 0.25 MAC Preferentially Affects Higher Order Association Areas: A Functional Magnetic Resonance Imaging Study in Volunteers
Ramani R, Qiu M, Constable RT. Sevoflurane 0.25 MAC Preferentially Affects Higher Order Association Areas: A Functional Magnetic Resonance Imaging Study in Volunteers. Anesthesia & Analgesia 2007, 105: 648-655. PMID: 17717218, PMCID: PMC2716177, DOI: 10.1213/01.ane.0000277496.12747.29.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowFunctional magnetic resonance imagingMAC sevofluraneMotor activation taskAssociation cortexMemory-related regionsAssociation areasVolatile anestheticsVisual cortexBaseline regional cerebral blood flowHigher-order association areasMagnetic resonance imaging studyHigher-order association corticesCerebral blood flowActivation taskSupplementary motor areaPrimary cortical regionsSecondary visual cortexPrimary visual cortexResonance imaging studyFunctional magnetic resonance imaging studyMagnetic resonance imagingArterial spin labeling techniqueASA ISubanesthetic doses