2008
Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects
Qiu M, Ramani R, Swetye M, Rajeevan N, Constable RT. Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects. Magnetic Resonance In Medicine 2008, 60: 987-996. PMID: 18816821, PMCID: PMC2716171, DOI: 10.1002/mrm.21759.Peer-Reviewed Original ResearchConceptsCerebral blood flowLow-dose sevofluraneRegional cerebral blood flowTask-induced changesBaseline cerebral blood flowBlood oxygen level-dependent (BOLD) signalAbsence of anesthesiaHealthy human subjectsHuman subjectsNormal human subjectsLevel-dependent signalFunctional MR imagingVascular measuresAnesthetic agentsBlood flowAnesthetic effectSevofluraneFunctional MRI dataAnesthesia conditionsAnesthesiaMR imagingAuditory regionsOxidative metabolismAuditory stimuliFMRI study
2007
Sevoflurane 0.25 MAC Preferentially Affects Higher Order Association Areas: A Functional Magnetic Resonance Imaging Study in Volunteers
Ramani R, Qiu M, Constable RT. Sevoflurane 0.25 MAC Preferentially Affects Higher Order Association Areas: A Functional Magnetic Resonance Imaging Study in Volunteers. Anesthesia & Analgesia 2007, 105: 648-655. PMID: 17717218, PMCID: PMC2716177, DOI: 10.1213/01.ane.0000277496.12747.29.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowFunctional magnetic resonance imagingMAC sevofluraneMotor activation taskAssociation cortexMemory-related regionsAssociation areasVolatile anestheticsVisual cortexBaseline regional cerebral blood flowHigher-order association areasMagnetic resonance imaging studyHigher-order association corticesCerebral blood flowActivation taskSupplementary motor areaPrimary cortical regionsSecondary visual cortexPrimary visual cortexResonance imaging studyFunctional magnetic resonance imaging studyMagnetic resonance imagingArterial spin labeling techniqueASA ISubanesthetic doses