Common Risk Alleles for Inflammatory Diseases Are Targets of Recent Positive Selection
Raj T, Kuchroo M, Replogle JM, Raychaudhuri S, Stranger BE, De Jager PL. Common Risk Alleles for Inflammatory Diseases Are Targets of Recent Positive Selection. American Journal Of Human Genetics 2013, 92: 517-529. PMID: 23522783, PMCID: PMC3617371, DOI: 10.1016/j.ajhg.2013.03.001.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesProtein-protein interaction networkRecent positive selectionPositive selectionInteraction networksExpression quantitative trait loci (eQTL) mapping studiesSelective pressureQuantitative trait locus (QTL) mapping studiesRecent positive natural selectionHundreds of lociPositive natural selectionFunctional genomics dataCis-regulatory effectsInflammatory disease susceptibilityHost resistanceSignificant selective pressureCommon risk allelesEvolutionary forcesMolecular functionsAssociated lociNatural selectionGenetic variationGenomic signaturesGenomic dataGene expression