2013
Alterations in Glucose Homeostasis in a Murine Model of Chagas Disease
Nagajyothi F, Kuliawat R, Kusminski CM, Machado FS, Desruisseaux MS, Zhao D, Schwartz GJ, Huang H, Albanese C, Lisanti MP, Singh R, Li F, Weiss LM, Factor SM, Pessin JE, Scherer PE, Tanowitz HB. Alterations in Glucose Homeostasis in a Murine Model of Chagas Disease. American Journal Of Pathology 2013, 182: 886-894. PMID: 23321322, PMCID: PMC3586686, DOI: 10.1016/j.ajpath.2012.11.027.Peer-Reviewed Original ResearchMeSH KeywordsAdipose Tissue, WhiteAnimalsBlood GlucoseChagas DiseaseDisease Models, AnimalFluorescent Antibody TechniqueGlucagonGluconeogenesisGlucoseHomeostasisInsulinLiverMaleMicePancreasTrypanosoma cruziConceptsPancreatic β-cellsChagas diseaseΒ-cellsGlucose-6-phosphatase mRNAChronic phaseInsulin levelsCruzi infectionGlucose homeostasisPlasma membraneInsulin granulesΒ-cell dysfunctionTrypanosoma cruziHost glucose homeostasisT. cruzi infectionElevated glucagon levelsΑ-cell functionAdrenergic receptor agonistDiminished insulin responsePancreatic islet architectureReduced insulinMice resultsAcute infectionCardiac dysfunctionGlucagon levelsPancreatic inflammation
2012
Altered Regulation of Akt Signaling with Murine Cerebral Malaria, Effects on Long-Term Neuro-Cognitive Function, Restoration with Lithium Treatment
Dai M, Freeman B, Shikani HJ, Bruno FP, Collado JE, Macias R, Reznik SE, Davies P, Spray DC, Tanowitz HB, Weiss LM, Desruisseaux MS. Altered Regulation of Akt Signaling with Murine Cerebral Malaria, Effects on Long-Term Neuro-Cognitive Function, Restoration with Lithium Treatment. PLOS ONE 2012, 7: e44117. PMID: 23082110, PMCID: PMC3474787, DOI: 10.1371/journal.pone.0044117.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsChloroquineCognitionFemaleFluorescent Antibody TechniqueGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaImmunoblottingLithiumMalaria, CerebralMiceMice, Inbred C57BLMotor ActivityParasitemiaPhosphorylationProto-Oncogene Proteins c-aktSignal TransductionTau ProteinsConceptsExperimental cerebral malaria modelMotor coordination deficitsAnti-parasitic treatmentChloroquine treatmentCoordination deficitsUninfected controlsLong-term neurological sequelaeCerebral malaria modelCerebral malaria patientsCognitive impairment persistsLong-term neuroMurine cerebral malariaNegative neurological outcomesPbA-infected micePlasmodium berghei ANKABrains of miceP. berghei NK65Adjunctive therapeutic targetManagement of CMAkt activationAkt/GSK3βVisual memory impairmentECM miceNeurological outcomeNeurological sequelae