2013
Alterations in Glucose Homeostasis in a Murine Model of Chagas Disease
Nagajyothi F, Kuliawat R, Kusminski CM, Machado FS, Desruisseaux MS, Zhao D, Schwartz GJ, Huang H, Albanese C, Lisanti MP, Singh R, Li F, Weiss LM, Factor SM, Pessin JE, Scherer PE, Tanowitz HB. Alterations in Glucose Homeostasis in a Murine Model of Chagas Disease. American Journal Of Pathology 2013, 182: 886-894. PMID: 23321322, PMCID: PMC3586686, DOI: 10.1016/j.ajpath.2012.11.027.Peer-Reviewed Original ResearchConceptsPancreatic β-cellsChagas diseaseΒ-cellsGlucose-6-phosphatase mRNAChronic phaseInsulin levelsCruzi infectionGlucose homeostasisPlasma membraneInsulin granulesΒ-cell dysfunctionTrypanosoma cruziHost glucose homeostasisT. cruzi infectionElevated glucagon levelsΑ-cell functionAdrenergic receptor agonistDiminished insulin responsePancreatic islet architectureReduced insulinMice resultsAcute infectionCardiac dysfunctionGlucagon levelsPancreatic inflammation
2012
Response of Adipose Tissue to Early Infection With Trypanosoma cruzi (Brazil Strain)
Nagajyothi F, Desruisseaux MS, Machado FS, Upadhya R, Zhao D, Schwartz GJ, Teixeira MM, Albanese C, Lisanti MP, Chua SC, Weiss LM, Scherer PE, Tanowitz HB. Response of Adipose Tissue to Early Infection With Trypanosoma cruzi (Brazil Strain). The Journal Of Infectious Diseases 2012, 205: 830-840. PMID: 22293433, PMCID: PMC3274374, DOI: 10.1093/infdis/jir840.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdiponectinAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsChagas DiseaseChemokinesCytokinesI-kappa B KinaseMaleMiceMitogen-Activated Protein KinasesNF-kappa BPPAR gammaReceptors, ChemokineRNA, MessengerSignal TransductionToll-Like Receptor 4Toll-Like Receptor 9Trypanosoma cruziConceptsWhite adipose tissueBrown adipose tissueAdipose tissueCruzi infectionNuclear factor kappa B (NF-κB) levelsToll-like receptor 4Peroxisome proliferator-activated receptor γProliferator-activated receptor γMRNA levelsTrypanosoma cruzi infectionMessenger RNA levelsReceptor 4Adipocyte sizeFat massHigher parasite loadsReceptor γEarly infectionExpression of componentsInfectionB levelsLipid accumulationRNA levelsParasite loadEarly targetProtein kinase pathway